Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response
| Autor: | Sarah Sportiche, Frank Bellivier, Pierre A. Geoffroy, Bruno Etain |
|---|---|
| Přispěvatelé: | Pôle Neurosciences, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neurologie - Psychiatrie, Fondation FondaMental [Créteil], Variabilité de réponse aux Psychotropes (VariaPsy - U1144), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5), Pôle de Psychiatrie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Assistance publique - Hôpitaux de Paris (AP-HP) - GH Saint-Louis - Lariboisière - Fernand Widal, Variabilité de réponse aux psychotropes (VariaPsy - U1144), Université Paris Diderot - Paris 7 (UPD7) - Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital H. Mondor - A. Chenevier, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) - Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR10, BMC, Ed. |
| Předmět: |
Oncology
medicine.medical_specialty Lithium carbonate Neurology Lithium (medication) Remission Lithium acetate Circadian genes chemistry.chemical_compound Mood stabilizers Internal medicine medicine In patient Circadian rhythms Recurrences Bipolar disorder Circadian rhythm [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Psychiatry Letter to the Editor Biological Psychiatry Chronobiology business.industry Mood stabilizer medicine.disease 3. Good health Psychiatry and Mental health chemistry Lithium salts [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Psychopharmacology business Sleep medicine.drug |
| Zdroj: | HAL International Journal of Bipolar Disorders International Journal of Bipolar Disorders, Springer Open, 2014, 2 (1), pp.5 |
| ISSN: | 2194-7511 |
| Popis: | International audience; Bipolar disorder (BD) is a common, severe mental disorder with a high recurrence rate. Lithium (Li) is the cornerstone of BD treatments to reduce recurrence, suicide, and mortality risks. However, only 30% of patients treated with Li achieve complete remission, and few markers of the response to treatment have yet been identified for application in routine practice. Circadian biomarkers may be relevant predictors of individual responses to Li because (1) Li has been shown to affect circadian rhythms, (2) disrupted circadian rhythms are a core expression of susceptibility to BD, and (3) circadian abnormalities during euthymia are associated with relapses. |
| Databáze: | OpenAIRE |
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