Histone Modifications in Mouse Pronuclei and Consequences for Embryo Development
| Autor: | Borsuk, E., Michalkiewicz, J., Kubiak, J.Z., Kloc, M. |
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| Přispěvatelé: | Faculty of Biology [Warsaw], University of Warsaw (UW), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Military Institute of Medicine, Warsaw, Houston Methodist Hospital [Houston, TX, USA], The University of Texas M.D. Anderson Cancer Center [Houston] |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine ISBN: 9783031065729 Results and Problems in Cell Differentiation Results and Problems in Cell Differentiation, 70, Springer Science and Business Media Deutschland GmbH, pp.397-415, 2022, ⟨10.1007/978-3-031-06573-6_14⟩ |
| Popis: | International audience; Epigenetic marks, such as DNA methylation and posttranslational modifications of core histones, are the key regulators of gene expression. In the mouse, many of these marks are erased during gamete formation and must be introduced de novo after fertilization. Some of them appear synchronously, but the others are deposited asynchronously and/or remain differently distributed on maternal and paternal chromatin. Although the mechanisms regulating these processes are not entirely understandable, it is commonly accepted that epigenetic reprogramming occurring during the first cell cycle of a mouse embryo is crucial for its further development. This chapter focuses on selected epigenetic modifications, such as DNA methylation, the introduction of histone variants, histones acetylation, phosphorylation, and methylation. Properly depositing these marks on maternal and paternal chromatin is crucial for normal embryonic development. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG. |
| Databáze: | OpenAIRE |
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