Analysis of predictive parameters for the development of radiation-induced pneumonitis
| Autor: | Yoshiyuki Kurose, Kumiko Kishimoto, Hiroto Matsuse, Norio Kodaka, Toru Yamagishi, Takeshi Oshio, Kayo Watanabe, Chihiro Nakano, Kumiko Niitsuma |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Bronchoalveolar lavage 010407 polymers medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system surfactant protein D Lymphocyte 01 natural sciences Gastroenterology Pulmonary function testing 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Lung cancer Pneumonitis lcsh:RC705-779 medicine.diagnostic_test vascular endothelial growth factor Radiation-Induced Pneumonitis business.industry matrix metallopeptidase-9 lcsh:Diseases of the respiratory system respiratory system medicine.disease radiation-induced pneumonitis 0104 chemical sciences respiratory tract diseases Vascular endothelial growth factor medicine.anatomical_structure chemistry lcsh:RC666-701 030220 oncology & carcinogenesis Surgery Original Article Cardiology and Cardiovascular Medicine business Blood sampling |
| Zdroj: | Annals of Thoracic Medicine, Vol 12, Iss 4, Pp 252-258 (2017) Annals of Thoracic Medicine |
| ISSN: | 1998-3557 1817-1737 |
| Popis: | Introduction: Prevention and effective treatment of radiation-induced pneumonitis (RP) could facilitate greater use of radiation therapy (RT) for lung cancer. The purpose of this study was to determine clinical parameters useful for early prediction of RP. Methods: Blood sampling, pulmonary function testing, chest computed tomography, and bronchoalveolar lavage (BAL) were performed in patients with pathologically confirmed lung cancer who had completed ≥60 Gy of RT, at baseline, shortly after RT, and at 1 month posttreatment. Results: By 3 months post-RT, 11 patients developed RP (RP group) and the remaining 11 patients did not (NRP group). RT significantly increased total cell counts and alveolar macrophages in BAL of the NRP group, whereas lymphocyte count was increased in both groups. Matrix metallopeptidase-9 (MMP-9) increased and vascular endothelial growth factor decreased significantly in the BAL fluid (BALF) of the RP group following RT. Serum surfactant protein D (SP-D) increased significantly in the NRP group. SP-D in BALF from the RP group increased significantly with a subsequent increase in serum SP-D. Pulmonary dilution decreased similarly in both groups of patients. Conclusions: Increased SP-D in BALF, rather than that in serum, could be useful biomarkers in predicting RP. The MMP-9 in BALF might play a role in the pathogenesis of RP. Pulmonary dilution test may not be predictive of the development of RP. |
| Databáze: | OpenAIRE |
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