Prolonged paralysis after long-term, high-dose infusion of pancuronium in anaesthetized cats
| Autor: | M. C. Houwertjes, A. den Hertog, Robert H. Henning, A. H. J. Scaf, Sandor Agoston |
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| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Pentobarbital Infusions Synaptic Transmission/drug effects Neuromuscular transmission Neuromuscular Junction 4-Aminopyridine/pharmacology Synaptic Transmission Pancuronium/administration & dosage Infusion Procedure Internal medicine Paralysis Medicine Animals Pancuronium 4-Aminopyridine Neuromuscular Junction/drug effects Infusions Intravenous CATS biology business.industry Muscle Contraction/drug effects Fissipedia Hemodynamics biology.organism_classification Neuromuscular monitoring Neostigmine Anesthesiology and Pain Medicine Endocrinology Hemodynamics/drug effects Anesthesia Cats medicine.symptom business Intravenous Neostigmine/pharmacology medicine.drug Muscle Contraction |
| Zdroj: | British Journal of Anaesthesia, 71(3), 393-397. ELSEVIER SCI LTD |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/71.3.393 |
| Popis: | We have studied the neuromuscular effects of a 48-h infusion of high-dose pancuronium (400 micrograms kg-1 h-1) in four cats anaesthetized with pentobarbitone, using contraction of tibialis anterior muscles after direct and indirect stimulation. After cessation of the pancuronium infusion, prolonged paralysis existed. The first twitch in the train-of-four stimuli (TOF) reappeared 8-12 h after termination of the pancuronium infusion. Twenty-four hours after termination of the infusion, TOF ratios were less than 0.08 and twitch contraction averaged 39 (SE 8)% of initial values. Twitch contraction after direct stimulation did not differ from initial values. Antagonism of paralysis was accomplished with neostigmine 60 micrograms kg-1 in two animals and neostigmine 90 micrograms kg-1 and 4-aminopyridine 500 micrograms kg-1 in the others. Steady-state plasma concentration of pancuronium (2000 ng ml-1) decreased rapidly after termination of the infusion, but then stabilized at about 130 ng ml-1. These results indicate that prolonged paralysis after long-term administration of high-dose pancuronium is caused primarily by failure of neuromuscular transmission, most likely caused by the persistent plasma concentrations of the drug in the pharmacologically active range. |
| Databáze: | OpenAIRE |
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