Functional State of Rat Heart Mitochondria in Experimental Hyperthyroidism

Autor: Vlada S. Starinets, Anna B. Nikiforova, Natalya I. Venediktova, Galina D. Mironova, Ilya Solomadin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
medicine.medical_specialty
QH301-705.5
Respiratory chain
Mitochondrion
medicine.disease_cause
Hyperthyroidism
Catalysis
Mitochondria
Heart
Article
respiratory complexes
Inorganic Chemistry
Lipid peroxidation
Superoxide dismutase
chemistry.chemical_compound
Oxygen Consumption
Internal medicine
energy metabolism
mitochondrial dysfunction
medicine
Animals
oxidative stress
Physical and Theoretical Chemistry
Biology (General)
Rats
Wistar
Molecular Biology
QD1-999
Spectroscopy
Palmitoylcarnitine
chemistry.chemical_classification
thyroid hormones
biology
Glutathione peroxidase
Organic Chemistry
General Medicine
Glutathione
Computer Science Applications
Rats
mitochondria
Chemistry
Disease Models
Animal
Thyroxine
Endocrinology
chemistry
biology.protein
Triiodothyronine
Lipid Peroxidation
Oxidative stress
Zdroj: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11744, p 11744 (2021)
ISSN: 1422-0067
DOI: 10.3390/ijms222111744
Popis: In this work, the effect of thyroxine on energy and oxidative metabolism in the mitochondria of the rat heart was studied. Hyperthyroidism was observed in experimental animals after chronic administration of T4, which was accompanied by an increase in serum concentrations of free triiodothyronine (T3) and thyroxine (T4) by 1.8 and 3.4 times, respectively. The hyperthyroid rats (HR) had hypertrophy of the heart. In HR, there was a change in the oxygen consumption in the mitochondria of the heart, especially when using palmitoylcarnitine. The assay of respiratory chain enzymes revealed that the activities of complexes I, I + III, III, IV increased, whereas the activities of complexes II, II + III decreased in heart mitochondria of the experimental animals. It was shown that the level of respiratory complexes of the electron transport chain in hyperthyroid rats increased, except for complex V, the quantity of which was reduced. The development of oxidative stress in HR was observed: an increase in the hydrogen peroxide production rate, increase in lipid peroxidation and reduced glutathione. The activity of superoxide dismutase in the heart of HR was higher than in the control. At the same time, the activity of glutathione peroxidase decreased. The obtained data indicate that increased concentrations of thyroid hormones lead to changes in energy metabolism and the development of oxidative stress in the heart of rats, which in turn contributes to heart dysfunction.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje