Beyond conventional antibiotics - new directions for combination products to combat biofilm
| Autor: | Bayramov Danir F, Neff Jennifer A |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.drug_class 030106 microbiology Antimicrobial peptides Antibiotics Pharmaceutical Science Context (language use) Article Microbiology 03 medical and health sciences Broad spectrum Antibiotic resistance Drug Delivery Systems Systemic antibiotics Anti-Infective Agents Medicine Animals Humans business.industry Biofilm Antimicrobial Anti-Bacterial Agents 030104 developmental biology Equipment and Supplies Biofilms Biochemical engineering business |
| Popis: | Medical device related infections are a significant and growing source of morbidity and mortality. Biofilm formation is a common feature of medical device infections that is not effectively prevented or treated by systemic antibiotics. Antimicrobial medical device combination products provide a pathway for local delivery of antimicrobial therapeutics with the ability to achieve high local concentrations while minimizing systemic side effects. In this review, we present considerations for the design of local antimicrobial delivery systems, which can be facilitated by modeling local pharmacokinetics in the context of the target device application. In addition to the need for local delivery, a critical barrier to progress in the field is the need to incorporate agents effective against biofilm. This article aims to review key properties of antimicrobial peptides that make them well suited to meet the demands of the next generation of antimicrobial medical devices, including broad spectrum activity, rapid and biocidal mechanisms of action, and efficacy against biofilm. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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