Distribution of Spiked Drugs between Milk Fat, Skim Milk, Whey, Curd, and Milk Protein Fractions: Expansion of Partitioning Models
| Autor: | Nancy W. Shappell, Sara J. Lupton, Weilin L. Shelver, Heldur Hakk |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Whey protein food.ingredient Flunixin 030106 microbiology Food Contamination 01 natural sciences 03 medical and health sciences chemistry.chemical_compound fluids and secretions food Casein Skimmed milk medicine Phenylbutazone Animals Food science Anthelmintic digestive oral and skin physiology 010401 analytical chemistry food and beverages General Chemistry Milk Proteins Thiamphenicol Anti-Bacterial Agents 0104 chemical sciences Milk Whey Proteins Pharmaceutical Preparations chemistry General Agricultural and Biological Sciences Salicylic acid medicine.drug |
| Zdroj: | Journal of Agricultural and Food Chemistry. 66:306-314 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | The distributions of eight drugs (acetaminophen, acetylsalicylic acid/salicylic acid, ciprofloxacin, clarithromycin, flunixin, phenylbutazone, praziquantel, and thiamphenicol) were determined in milk products (skim milk, milk fat, curd, whey, and whey protein) and used to expand a previous model (from 7 drugs to 15 drugs) for predicting drug distribution. Phenylbutazone and praziquantel were found to distribute with the lipid and curd phases (≥50%). Flunixin distribution was lower but similar in direction (12% in milk fat, 39% in curd). Acetaminophen, ciprofloxacin, and praziquantel preferentially associated with casein proteins, whereas thiamphenicol and clarithromycin associated preferentially to whey proteins. Regression analyses for log [milk fat]/[skim milk] and log [curd]/[whey] had r2 values of 0.63 and 0.67, respectively, with p of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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