Pregnancy outcomes, infant mortality, and arsenic in drinking water in West Bengal, India
| Autor: | S Das, Yan Yuan, David A. Kalman, D N Guha Mazumder, Sarbari Lahiri, O S von Ehrenstein, A. Ghosh, Allan H. Smith, Meera Hira-Smith, Gayle C. Windham, Nilima Ghosh, Reina Haque |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Epidemiology Population India Abortion Interviews as Topic Pregnancy Risk Factors Arsenic Poisoning Infant Mortality medicine Humans education Gynecology education.field_of_study business.industry Obstetrics Infant Newborn Pregnancy Outcome Confounding Factors Epidemiologic Odds ratio medicine.disease Infant mortality Arsenic contamination of groundwater Logistic Models Gestation Female business Water Pollutants Chemical |
| Zdroj: | American journal of epidemiology. 163(7) |
| ISSN: | 0002-9262 |
| Popis: | Between 2001 and 2003, the authors studied pregnancy outcomes and infant mortality among 202 married women in West Bengal, India. Reproductive histories were ascertained using structured interviews. Arsenic exposure during each pregnancy, including all water sources used, was assessed; this involved measurements from 409 wells. Odds ratios for spontaneous abortion, stillbirth, neonatal mortality, and infant mortality were estimated with logistic regression based on the method of generalized estimating equations. Exposure to high concentrations of arsenic (> or =200 microg/liter) during pregnancy was associated with a sixfold increased risk of stillbirth after adjustment for potential confounders (odds ratio (OR) = 6.07, 95% confidence interval (CI): 1.54, 24.0; p = 0.01). Arsenic-related skin lesions were found in 12 women who had a substantially increased risk of stillbirth (OR = 13.1, 95% CI: 3.17, 54.0; p = 0.002). The odds ratio for neonatal death was 2.81 (95% CI: 0.73, 10.8). No association was found between arsenic exposure and spontaneous abortion (OR = 1.01, 95% CI: 0.38, 2.70) or overall infant mortality (OR = 1.33, 95% CI: 0.43, 4.04). This study adds to the limited evidence that exposure to high concentrations of arsenic during pregnancy increases the risk of stillbirth. However, there was no indication of the increased rates of spontaneous abortion and overall infant mortality that have been reported in some studies. |
| Databáze: | OpenAIRE |
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