Effects of transcranial direct current stimulation (tDCS) on executive functions: influence of COMT Val/Met polymorphism

Autor: Bastian Zwissler, Rejko Krüger, Brigitte Maurer, Katrin Elisabeth Giel, Christian Plewnia, Isabella Längst
Rok vydání: 2012
Předmět:
Adult
Male
Heterozygote
Genotype
Cognitive Neuroscience
medicine.medical_treatment
physiology [Prefrontal Cortex]
Dopamine
genetics [Catechol O-Methyltransferase]
Prefrontal Cortex
Experimental and Cognitive Psychology
Stimulation
genetics [Polymorphism
Genetic]
Catechol O-Methyltransferase
Polymerase Chain Reaction
physiology [Psychomotor Performance]
genetics [Amino Acid Substitution]
Executive Function
Young Adult
physiology [Brain]
Double-Blind Method
physiology [Dopamine]
Neuroplasticity
medicine
Humans
Attention
ddc:610
genetics [DNA]
Cross-Over Studies
Polymorphism
Genetic
Transcranial direct-current stimulation
Dopaminergic
Cognitive flexibility
Brain
Cognition
DNA
Executive functions
Electric Stimulation
physiology [Executive Function]
Inhibition
Psychological
Neuropsychology and Physiological Psychology
Amino Acid Substitution
Brain stimulation
physiology [Attention]
Set
Psychology
Female
Psychology
Neuroscience
Psychomotor Performance
Zdroj: Cortex 49(7), 1801-1807 (2013). doi:10.1016/j.cortex.2012.11.002
ISSN: 1973-8102
DOI: 10.1016/j.cortex.2012.11.002
Popis: Introduction Transcranial direct current stimulation (tDCS) is a frequently used technique to investigate healthy and impaired neuronal functions. Its modulatory effect on executive functions is of particular interest for understanding the mechanisms underlying integration of cognition and behavior. The key role of prefrontal dopamine function for executive functions suggest that differences of the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene would interact with tDCS interventions in this domain. In this study, we hypothesized that the COMT Met allele homozygosity, associated with higher levels of prefrontal dopamine, would influence the effect of tDCS on higher-level executive functions. Method Forty-six healthy subjects participated in a double-blind sham-controlled crossover study and underwent COMT genotyping. Anodal tDCS (20 min, 1 mA) to the left dorsolateral prefrontal cortex (dlPFC) or sham stimulation was applied during the performance of a parametric Go/No-Go (PGNG) test measuring sustained attention, response inhibition and cognitive flexibility as measured by set-shifting. Results In COMT Met/Met allele carrier anodal tDCS of the dlPFC was associated with a deterioration of set-shifting ability, which is assessed by the most challenging level of the PGNG. Without regard to the carrier status of the COMT Val158Met polymorphism no effects of anodal tDCS on executive functions could be determined. Conclusions In line with the model of non-linear effects of l -dopa on cortical plasticity high dopaminergic prefrontal activity mediated by COMT Val158Met polymorphism predicts a detrimental effect of anodal tDCS on cognitive flexibility. Therefore, we suggest that the individual genetic profile may modulate behavioral effect of tDCS. More precise application of brain stimulation techniques according to the individual genetic patterns may support the development of personalized treatment approaches.
Databáze: OpenAIRE
Externí odkaz: