Can functional walk tests add value to the prediction of cardiorespiratory fitness after stroke? A prospective cohort study

Autor: Mari Gunnes, Turid Follestad, Bent Indredavik, Torunn Askim, Inger-Lise Aamot Aksetøy
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Physiology
medicine.medical_treatment
Walking
030204 cardiovascular system & hematology
Vascular Medicine
law.invention
0302 clinical medicine
Medical Conditions
Mathematical and Statistical Techniques
Randomized controlled trial
law
Modified Rankin Scale
Medicine and Health Sciences
Medicine
Public and Occupational Health
Treadmill
Prospective cohort study
Stroke
Multidisciplinary
Rehabilitation
Respiration
Statistics
Middle Aged
Sports Science
Hemorrhagic Stroke
Neurology
Cardiorespiratory Fitness
Physical Sciences
Female
Gait Analysis
Research Article
Adult
medicine.medical_specialty
Cerebrovascular Diseases
Science
Walk Test
Research and Analysis Methods
03 medical and health sciences
Oxygen Consumption
Humans
Statistical Methods
Sports and Exercise Medicine
Exercise
Aged
business.industry
Biological Locomotion
Biology and Life Sciences
Cardiorespiratory fitness
Physical Activity
medicine.disease
Physical Fitness
Physical therapy
business
Physiological Processes
human activities
030217 neurology & neurosurgery
Mathematics
Forecasting
Zdroj: PLoS ONE, Vol 16, Iss 8, p e0255308 (2021)
PLOS ONE
PLoS ONE
PLoS ONE, Vol 16, Iss 8 (2021)
ISSN: 1932-6203
Popis: Background Cardiorespiratory fitness is often impaired following stroke, and peak oxygen consumption (VO2peak) is an important prognostic value of all-cause mortality. The primary objective was to investigate whether functional walk tests assessed in the subacute phase after stroke added value in predicting VO2peak in chronic stroke, in addition to age, sex and functional dependency. Secondary objectives were to investigate associations between daily physical activity and functional walk tests, and with VO2peak in chronic stroke. Methods This prospective cohort study included eligible participants originally included in the randomized controlled trial Life After Stroke. Functional walk tests, i.e., six-minute walk test (6MWT) and maximal gait speed, were assessed at inclusion and 18 months later. VO2peak [ml/kg/min] was assessed by a cardiopulmonary exercise test on a treadmill 20 months after inclusion. Daily physical activity was measured by a uniaxial accelerometer (activPAL) at 18-month follow-up. Results Ninety-two community-dwelling individuals, with a mean (SD) age of 69.2 (10.6) years and 33 (35.9%) women, were included 3 months after stroke onset. Eighty-three (90.2%) participants had a modified Rankin Scale (mRS) score of 1 or 2, indicating functional independence. An overall assessment of four prediction models indicated the combination of age, sex, mRS and 6MWT as predictors to be the best fitted model in predicting VO2peak (adjusted R2 = 0.612). Secondary results showed statistically significant, but not clinically significant, associations between daily physical activity and functional walk tests, and with VO2peak. Conclusions 6MWT add significant value to the prediction of mean VO2peak in the chronic phase in mild strokes, in combination with age, sex and functional dependency. This prediction model may facilitate clinical decisions and rehabilitation strategies for mildly affected stroke survivors in risk of low levels of VO2peak. Future studies should validate the model in various stages after stroke and in patients moderately and severely affected.
Databáze: OpenAIRE
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