Headache related alterations of visual processing in migraine patients
| Autor: | Gianluca Coppola, Jean Schoenen, Romain Nonis, Alain Maertens De Noordhout, Marco Lisicki, Vincenzo Parisi, Delphine Magis, Kevin D'Ostilio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual perception Sensory processing Migraine Disorders medicine.medical_treatment feedback Audiology Visual processing Young Adult 03 medical and health sciences 0302 clinical medicine Chronic Migraine 030202 anesthesiology chronic migraine episodic migraine feedforward spectral analysis Visual evoked potentials medicine Humans Ictal Visual Cortex business.industry Middle Aged medicine.disease Brain Waves Electrophysiology Anesthesiology and Pain Medicine Visual cortex medicine.anatomical_structure Neurology Migraine Chronic Disease Visual Perception Evoked Potentials Visual Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Popis: | Migraine is characterized by an increased sensitivity to visual stimuli that worsens during attacks. Recent evidence has shown that feedforward volleys carrying incoming visual information induce high-frequency (gamma) oscillations in the visual cortex, while feedback volleys arriving from higher order brain areas induce oscillatory activity at lower frequencies (theta/alpha/low beta). We investigated visually induced high (feedforward) and low (feedback) frequency activations in healthy subjects and various migraine patients. Visual evoked potentials from 20 healthy controls and 70 migraine patients (30 interictal and 20 ictal episodic migraineurs, 20 chronic migraineurs) were analyzed in the frequency domain. We compared power in the theta-alpha-low beta and gamma range between groups, and searched for correlations between the low-to-high frequency activity ratio and number of monthly headache and migraine days. Compared to healthy controls, interictal migraine patients had increased visually induced low frequency (feedback) activity. Conversely, ictal and chronic migraine patients showed an augmented gamma band (feedforward) power. The low-frequency-to-gamma (feedback/feedforward) activity ratio correlated negatively with monthly headache days and tended to do so with migraine days. Our findings show that visual processing is differentially altered depending on migraine cycle and type. Feedback control from higher order cortical areas predominates interictally in episodic migraine while migraine attacks and chronic migraine are associated with enhanced incoming afferent activity, confirming their similar electrophysiological profile. The presence of headache is associated with proportionally higher gamma (feedforward) activities. PERSPECTIVE: This study provides an insight into the pathophysiology of migraine headache from the perspective of cortical sensory processing dynamics. Patients with migraine present alterations in feedback and feedforward visual signaling that differ with the presence of headache. |
| Databáze: | OpenAIRE |
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