Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
| Autor: | Virginie F. Labrousse, Thomas Larrieu, Anais Duffaud, Carlos Matute, Sophie Layé, Olivier J. Manzoni, Véronique De Smedt-Peyrusse, Marja D. Sepers, Lionel Bretillon, Isabelle Matias, Susana Mato, Mathieu Lafourcade, Rafael Rodríguez-Puertas |
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| Přispěvatelé: | Unité de Psychoneuroimmunologie, Nutrition et Génétique (PsyNuGen), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Physiopathology of synaptic plasticity, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Bordeaux Segalen - Bordeaux 2 |
| Rok vydání: | 2010 |
| Předmět: |
Plasticity
medicine.medical_treatment Emotions Prefrontal Cortex Biology Nucleus Accumbens 03 medical and health sciences Mice 0302 clinical medicine Receptor Cannabinoid CB1 Receptors [SDV.IDA]Life Sciences [q-bio]/Food engineering Cannabinoid Receptor Modulators Fatty Acids Omega-3 medicine Animals Humans Behaviour [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering Prefrontal cortex Receptor 030304 developmental biology 2. Zero hunger chemistry.chemical_classification Neurons 0303 health sciences Neuronal Plasticity Behavior Animal Effector General Neuroscience Malnutrition Western Diets Endocannabinoid system Psychiatric Disorders 3. Good health Diet Mice Inbred C57BL chemistry Synapses Emotional behavior lipids (amino acids peptides and proteins) Female Cannabinoid Neuroscience 030217 neurology & neurosurgery Polyunsaturated fatty acid Endocannabinoids |
| Zdroj: | Nature Neuroscience Nature Neuroscience, Nature Publishing Group, 2011, 14 (3), pp.345-350. ⟨10.1038/nn.2736⟩ Nature Neuroscience, Nature Publishing Group, 2011, ⟨10.1038/nn.2736⟩ |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | International audience; The corollaries of the obesity epidemic that plagues developed societies are malnutrition and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty acids (n-3 PUFAs) have been linked to neuropsychiatric diseases, but the underlying synaptic alterations are mostly unknown. We found that lifelong n-3 PUFAs dietary insufficiency specifically ablates long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens. In n-3 deficient mice, presynaptic cannabinoid CB1 receptors (CB1Rs) normally responding to endocannabinoids were uncoupled from their effector Gi/o-proteins. Finally, the dietary-induced reduction of CB1R functions in mood controlling structures is associated with impaired emotional behavior. These findings identify a plausible synaptic substrate for the behavioral alterations caused by the n-3 PUFAs deficiency often observed in western diets |
| Databáze: | OpenAIRE |
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