Quantitative evaluation of range and metabolic activity of hepatic alveolar echinococcosis lesion microenvironment using PET/CT and multi-site sampling method
| Autor: | Aimaiti Yasen, Yingmei Shao, Jian Wang, Zhide Li, Xiaohong Li, Abuduaini Abulizi, Tuerganaili Aji, Maiweilidan Yimingjiang, Tiemin Jiang, Hao Wen, Abudusalamu Aini, Bo Ran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Echinococcosis Hepatic Medication history PET/CT Multi-site sampling (MSS) Alveolar echinococcosis Infectious and parasitic diseases RC109-216 Lesion 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Lesion microenvironment (LME) Positron Emission Tomography Computed Tomography medicine Tumor Microenvironment Humans Prospective Studies Hepatic Alveolar Echinococcosis Retrospective Studies PET-CT Alveolar echinococcosis (AE) Chemistry business.industry Multi site Middle Aged Immune infiltration Infectious Diseases 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female Abdominal computed tomography medicine.symptom Metabolic activity Nuclear medicine business Research Article |
| Zdroj: | BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-11 (2021) BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| Popis: | Background Alveolar echinococcosis (AE) lesion microenvironment (LME) is crucial site where parasite-host interactions happen and of great significance during surgery and obtaining liver samples for basic research. However, little is known about quantification of LME range and its’ metabolic activity regarding different lesion characteristics. Methods A prospective and retrospective analysis of LME from surgical AE patients was performed. Patients (n = 75) received abdominal computed tomography (CT) and position emission tomography/computed tomography using 18F-fluodeoxyglucose (18F-FDG-PET/CT) within 1 week prior to surgery. Semiquantitatively, calcification was clustered with 0%, 18F-FDG standard uptake value (SUV, n = 75) was calculated, and range of 18F-FDG uptake area was measured; Multi-site sampling method (MSS, n = 35) was introduced to obtain histological slides to evaluate immune cell infiltrative ranges. Results Altogether six major lesion groups have been identified (A: 0% calcified, 0% liquefied; B: ≥50% calcified, 0% liquefied; C: B, A > D, A > F, E > B, E > D, E > F, C > B, C > D, C > F (P B, A > D, A > F, A > E, C > B, C > D, C > F, E > D, E > F, B > D, B > F (P C, A > D, A > F, B > D, B > F, C > D, C > F (P Conclusions PET/CT and MSS method showed distinct TBRs and LME ranges for different calcifications and liquefactions. This study would be able to provide references for both surgical resections of lesions and more accurate sample acquisitions for basic research targeted to immunology. |
| Databáze: | OpenAIRE |
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