Qualitative and quantitative measurements of oligonucleotides in gene therapy: Part II in vivo models
| Autor: | Hemant K. Tewary, Patrick L. Iversen |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Stereochemistry
Genetic enhancement Clinical Biochemistry Oligonucleotides Pharmaceutical Science Cell free Sulfur Radioisotopes Biological fluid Analytical Chemistry In vivo Drug Discovery Animals Humans Tissue Distribution Chromatography High Pressure Liquid Spectroscopy Clinical Trials Phase I as Topic Chemistry Oligonucleotide Genetic Therapy Biological materials In vitro Body Fluids Spectrometry Fluorescence Biochemistry Electrophoresis Polyacrylamide Gel Phosphorus Radioisotopes Quantitative analysis (chemistry) |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 15:1127-1135 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/s0731-7085(97)01942-0 |
| Popis: | Part I of this review has already been presented on methods of processing and purification of crude or raw samples in cell-culture or cell free systems. Part II of the review focuses on the in vivo models of determination of input oligonucleotides in both non-primates and primates. Emphasis has been given to the techniques developed for quantification of oligonucleotides or their metabolites from biological samples including blood, plasma, serum, urine and other tissues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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