Childhood Sjögren syndrome: Features of an international cohort and application of the 2016 ACR/EULAR classification criteria
| Autor: | Juan Manuel Mosquera, Rachel L Randell, Sara M Stern, Alexis Boneparth, Jonathan D Akikusa, Baruch Goldberg, Matthew L. Basiaga, Kathleen M. O'Neil, Brian Dizon, Jordi Anton, Akaluck Thatayatikom, Ninela Irga-Jaworska, Anna Pomorska, Cuoghi Edens, Jay J. Mehta, Juan Carlos Nieto-González, Hemalatha Srinivasalu, Seunghee Cha, Stella A Protopapas, Rebecca Nicolai, Scott M. Lieberman, Mindy S. Lo, Simone Appenzeller, Claudia Bracaglia, Erin Brennan Treemarcki, Claudia Saad-Magalhães, Naoto Yokogawa, Ankur A. Kamdar, Maria Ibarra, Gordana Susic, Sheila Knupp-Oliveira |
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| Přispěvatelé: | Mayo Clinic, University of Utah School of Medicine, The Children's Hospital of Philadelphia, The University of Chicago Medical Center, Duke University School of Medicine, Medical University of Gdansk, University of Missouri-Kansas City, Irccs Ospedale Pediatrico Bambino Gesù, Institute of Rheumatology, Columbia University Medical Center, George Washington University School of Medicine and Health Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases, University of Texas McGovern Medical School at Houston, Emory University School of Medicine, Universidade Federal do Rio de Janeiro (UFRJ), Hospital Sant Joan de Déu, Barcelona, Universidade Estadual de Campinas (UNICAMP), Riley Hospital for Children at Indiana University Health, Universidade Estadual Paulista (UNESP), Melbourne and Murdoch Children's Research Institute, University of Florida, Hospital General Universitario Gregorio Marañón, Harvard Medical School, Tokyo Metropolitan Tama Medical Center, University of Iowa |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
musculoskeletal diseases Pediatrics medicine.medical_specialty Neutropenia Adolescent Population recurrent parotitis childhood Sjögren syndrome Sjögren syndrome Xerostomia Cohort Studies Rheumatology Rheumatoid Factor Hypergammaglobulinemia Lymphopenia medicine Humans Pharmacology (medical) Age of Onset Pediatric rheumatology pediatric rheumatology Child education skin and connective tissue diseases education.field_of_study Sjögren Syndrome business.industry Infant Diagnostic test Recurrent parotitis Clinical Science medicine.disease Arthralgia Thrombocytopenia Sjogren's Syndrome Antibodies Antinuclear Child Preschool Cohort Dry Eye Syndromes Female business Parotitis |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Rheumatology r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname Rheumatology (Oxford) |
| ISSN: | 1462-0324 |
| Popis: | Made available in DSpace on 2022-04-29T08:30:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-07-01 Objective: Sjögren syndrome in children is a poorly understood autoimmune disease. We aimed to describe the clinical and diagnostic features of children diagnosed with Sjögren syndrome and explore how the 2016 ACR/EULAR classification criteria apply to this population. Methods: An international workgroup retrospectively collected cases of Sjögren syndrome diagnosed under 18 years of age from 23 centres across eight nations. We analysed patterns of symptoms, diagnostic workup, and applied the 2016 ACR/EULAR classification criteria. Results: We identified 300 children with Sjögren syndrome. The majority of patients n = 232 (77%) did not meet 2016 ACR/EULAR classification criteria, but n = 110 (37%) did not have sufficient testing done to even possibly achieve the score necessary to meet criteria. Even among those children with all criteria items tested, only 36% met criteria. The most common non-sicca symptoms were arthralgia [n = 161 (54%)] and parotitis [n = 140 (47%)] with parotitis inversely correlating with age. Conclusion: Sjögren syndrome in children can present at any age. Recurrent or persistent parotitis and arthralgias are common symptoms that should prompt clinicians to consider the possibility of Sjögren syndrome. The majority of children diagnosed with Sjögren syndromes did not meet 2016 ACR/EULAR classification criteria. Comprehensive diagnostic testing from the 2016 ACR/EULAR criteria are not universally performed. This may lead to under-recognition and emphasizes a need for further research including creation of paediatric-specific classification criteria. Division of Pediatric Rheumatology Department of Pediatric and Adolescent Medicine Mayo Clinic Division of Rheumatology Department of Pediatrics University of Utah School of Medicine Division of Rheumatology The Children's Hospital of Philadelphia Department of Internal Medicine and Pediatrics The University of Chicago Medical Center Department of Pediatrics Duke University School of Medicine Department of Pediatrics Hematology and Oncology Medical University of Gdansk Children's Mercy Hospital University of Missouri-Kansas City Division of Rheumatology Irccs Ospedale Pediatrico Bambino Gesù Department of Pediatric Rheumatology Institute of Rheumatology Department of Pediatrics Columbia University Medical Center Division of Rheumatology Children's National Hospital George Washington University School of Medicine and Health Sciences National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases Department of Pediatrics University of Texas McGovern Medical School at Houston Division of Pediatric Rheumatology Children's Healthcare of Atlanta Emory University School of Medicine Instituto de Puericultura e Pediatria Martagão Gesteira Universidade Federal Do Rio de Janeiro Pediatric Rheumatology Hospital Sant Joan de Déu Universitat de Barcelona Barcelona Rheumatology Unit Department of Medicine School of Medical Science University of Campinas Division of Rheumatology Department of Pediatrics University of Indiana School of Medicine Riley Hospital for Children at Indiana University Health Pediatric Rheumatology Unit São Paulo State University (UNESP), Botucatu Rheumatology Service Royal Children's Hospital Melbourne and Murdoch Children's Research Institute Division of Pediatric Allergy Immunology and Rheumatology Department of Pediatrics College of Medicine University of Florida Division of Oral Medicine Department of Oral and Maxillofacial Diagnostic Sciences College of Dentistry University of Florida Rheumatology Department Hospital General Universitario Gregorio Marañón Division of Immunology Boston Children's Hospital Department of Pediatrics Harvard Medical School Department of Rheumatic Diseases Tokyo Metropolitan Tama Medical Center Division of Rheumatology Allergy and Immunology Stead Family Department of Pediatrics Carver College of Medicine University of Iowa Pediatric Rheumatology Unit São Paulo State University (UNESP), Botucatu |
| Databáze: | OpenAIRE |
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