Impact of mean blood pressure and blood pressure variability after diagnosis of mild cognitive impairment and risk of dementia
| Autor: | Adam de Havenon, Mohammad Anadani, Shyam Prabhakaran, Varsha Muddasani |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
hypertension Endocrinology Diabetes and Metabolism Diastole Blood Pressure mild cognitive impairment Alzheimer Disease Internal medicine mental disorders Internal Medicine Short Research Article Humans Medicine Dementia Cognitive Dysfunction Cognitive impairment Proportional Hazards Models business.industry public health Hazard ratio visit‐to‐visit blood pressure variability Montreal Cognitive Assessment vascular dementia cognitive disorders/dementia Alzheimer's disease medicine.disease Short Research Articles Mean blood pressure Blood pressure Quartile insular cortex Commentary Cardiology blood pressure variability Cardiology and Cardiovascular Medicine business Biomarkers dementia |
| Zdroj: | The Journal of Clinical Hypertension |
| ISSN: | 1751-7176 1524-6175 |
| Popis: | Hypertension and increased blood pressure variability (BPV) are associated with the development of dementia. However, previous studies did not focus on the risk of dementia among participants with mild cognitive impairment (MCI) and controlled blood pressure level. To address this limitation, the authors performed a post‐hoc analysis of SPRINT MIND participants diagnosed with MCI (mean Montreal Cognitive Assessment score at diagnosis 16.1±3.1). The primary outcome was subsequent diagnosis of probable dementia. The exposure was mean blood pressure and BPV following MCI diagnosis until the end of follow‐up or a dementia event (mean follow‐up 2.6±1.2 years). The primary outcome occurred in 76/516 (14.7%) patients. The mean blood pressure was not significantly higher in participants who developed dementia. In the lowest quartile of BPV (systolic standard deviation), the rate of dementia was 8.5% (11/129), while in the highest quartile it was 21.7% (28/129). The highest quartile of systolic BPV had an adjusted hazard ratio for dementia of 2.73 (95% CI, 1.31–5.69) and for diastolic BPV it was 2.62 (95% CI, 1.26–5.47). In SPRINT MIND participants, the authors found that increased BPV after MCI diagnosis was associated with incident probable dementia during subsequent follow‐up. |
| Databáze: | OpenAIRE |
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