Increase in FoxP3, CD56 immune cells and decrease in glands PGRMC1 expression in the endometrium are associated with recurrent miscarriages
| Autor: | Dmitry Aleksandrovich Zinovkin, Yulia Anatolievna Lyzikova, Zahidul Islam Pranjol |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Abortion Habitual Republic of Belarus chemical and pharmacologic phenomena Endometrium T-Lymphocytes Regulatory Andrology 03 medical and health sciences 0302 clinical medicine Immune system Pregnancy Recurrent miscarriage medicine Humans Genetic Predisposition to Disease Prospective Studies 030212 general & internal medicine Prospective cohort study PGRMC1 030219 obstetrics & reproductive medicine biology business.industry Uterus Membrane Proteins Obstetrics and Gynecology FOXP3 Forkhead Transcription Factors hemic and immune systems medicine.disease Primary and secondary antibodies CD56 Antigen Killer Cells Natural Parity medicine.anatomical_structure Reproductive Medicine biology.protein Immunohistochemistry Female Receptors Progesterone business |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 245:121-126 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2019.12.019 |
| Popis: | Objective Recurrent miscarriage (RM) is a multifactorial condition that involves frequent uterine anatomical abnormalities, parental karyotype abnormalities, and clotting disorders. We investigate the potential roles of endometrium FoxP3+ Tregs and CD56+ cells (uNK cells) and endometrial expression of PGRMC1 in the development of recurrent miscarriage. Study design This prospective study included 102 out of 286 cases of SA patients. The cases were divided into groups with RM (+RM) and without RM (-RM). Immunohistochemistry staining was made using primary antibodies to FoxP3, CD56, and PGRMC1 in both groups. Morphometry analyses were carried out in 10 non-overlapping high power fields. Mann-Whitney U test, Fisher two-tail test, correlation analysis and relative risk (RR) were evaluated. A p Results An increased presence of CD56-positive (p Conclusion Our prospective study suggests, for the first time, that increased endometrial infiltration of uNK, FoxP3+ Treg cells and a decreased PGRMC1 expression may play potential roles in the development of RM. |
| Databáze: | OpenAIRE |
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