Toxicity and tissue distribution of the schistosomicide TWSb (RO 41544/6) in rats
| Autor: | Robert E. Bagdon, Gerhard Zbinden |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Antimony
Slow rate Antiprotozoal Agents Blood count Pharmacology Kidney Toxicology Injections Intramuscular Schistosomicides medicine Schistosomiasis Tissue Distribution Tissue distribution Blood Chemical Analysis Chemistry Research Succinates Rats Intestines medicine.anatomical_structure Liver Toxicity Antimonial General health |
| Zdroj: | Toxicology and Applied Pharmacology. 6:214-219 |
| ISSN: | 0041-008X |
| Popis: | Toxicity measurements of the schistosomicide TWSb indicate this trivalent antimonial to be well tolerated by rats given daily intramuscular injections of 100 mg/kg, 10 mg/kg, and 1 mg/kg for 15 weeks; these doses are equivalent to daily administration of 25 mg/kg, 2.5 mg/kg, and 0.25 mg/kg of antimony. The parameters measured include observation of general health, blood counts, and gross and microscopic examination of the tissues. Single intramuscular doses of 100 mg/kg or 1 mg/kg of TWSb produced high levels of antimony in serum and tissues after 1 hour, and significant amounts were still present after 144 hours. The peak concentrations of antimony in intestines occurred at a later time interval than observed in serum, liver, or kidneys, suggesting that the drug is excreted via the biliary route at a relatively slow rate. |
| Databáze: | OpenAIRE |
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