Label-free classification of colon cancer grading using infrared spectral histopathology
| Autor: | Andrea Tannapfel, Angela Kallenbach-Thieltges, Klaus Gerwert, Axel Mosig, Claus Kuepper, Frederik Großerueschkamp |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Neoplasm Grading Spectrophotometry Infrared business.industry Colorectal cancer 010401 analytical chemistry Precision medicine medicine.disease 01 natural sciences 0104 chemical sciences 03 medical and health sciences Tumour tissue 030104 developmental biology Colonic Neoplasms medicine Tumour grading Humans Histopathology Radiology Physical and Theoretical Chemistry business Grading (tumors) Label free |
| Zdroj: | Faraday discussions. 187 |
| ISSN: | 1364-5498 |
| Popis: | In recent years spectral histopathology (SHP) has been established as a label-free method to identify cancer within tissue. Herein, this approach is extended. It is not only used to identify tumour tissue with a sensitivity of 94% and a specificity of 100%, but in addition the tumour grading is determined. Grading is a measure of how much the tumour cells differ from the healthy cells. The grading ranges from G1 (well-differentiated), to G2 (moderately differentiated), G3 (poorly differentiated) and in rare cases to G4 (anaplastic). The grading is prognostic and is needed for the therapeutic decision of the clinician. The presented results show good agreement between the annotation by SHP and by pathologists. A correlation matrix is presented, and the results show that SHP provides prognostic values in colon cancer, which are obtained in a label-free and automated manner. It might become an important automated diagnostic tool at the bedside in precision medicine. |
| Databáze: | OpenAIRE |
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