Disorder of Endothelia Vessels' Functional State with Malignant Tumors in Patients Exposed Anthropogenic Radiation
| Autor: | Nobuo Takeichi, Sayakhat Lzhaev, Zukhra Anambaeva, Ainur Argynbekova, Gulyash Tanysheva, Ainur Baissalbayeva, Yoshihiro Noso, Tolebay Rakhypbekov, Raikhan Tuleutayeva, Tasbolat Adylkhanov, Laura Pak, Lashyn Zhazykbayeva, Nailya Chaizhunusova, Daniyar Aldyngurov |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Endothelium Epidemiology Vasodilation 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Von Willebrand factor Radiation Ionizing von Willebrand Factor medicine Humans Platelet Endothelial dysfunction Aged Gastrointestinal Neoplasms Hemostasis Gastrointestinal tract biology business.industry Public Health Environmental and Occupational Health Cancer Middle Aged Prognosis medicine.disease Kazakhstan medicine.anatomical_structure Oncology Case-Control Studies 030220 oncology & carcinogenesis biology.protein Female Endothelium Vascular business Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 17:575-579 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2016.17.2.575 |
| Popis: | The aim of this research is to determine the characteristics of endothelial factors and the hemostatic system conditions with malignant neoplasms patients, which were exposed to ionizing radiation. Total number of examined people is 223, 153 of them are patients with gastrointestinal tract oncopathology. The article presents the results of the analysis of numerical indicators of endothelial condition and platelet hemostasis of patients, who had cancer. They lived in the regions of Kazakhstan, subjected to contamination of radionuclides as a result of nuclear weapons tests, which took place in this region from 1949 to 1989. These results then were compared to cancer patients and healthy individuals with no radiation risk. The study revealed the presence of higher levels of endothelial dysfunction and following trigger of the hemostatic system in patients with malignant tumors of the gastrointestinal tract. In particular, the defined high degree of endothelial dysfunction include endothelium- dependent vasodilation, content desquamated endothelial cells in peripheral blood and von Willebrand factor. These indicators have a clear correlation with the degree of disorder of studied parameters of the hemostasis, which can cause the development of thrombotic complications. |
| Databáze: | OpenAIRE |
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