Resting-State Magnetoencephalography Reveals Different Patterns of Aberrant Functional Connectivity in Combat-Related Mild Traumatic Brain Injury

Autor: Deborah L. Harrington, Hauke Bartsch, Tao Song, Dewleen G. Baker, Anders M. Dale, Mithun Diwakar, Scott C. Matthews, Ashley Robb Swan, Charles Huang, Angela Drake, Jeffrey W Huang, Mingxiong Huang, Victoria B. Risbrough, Sharon Nichols, Annemarie Angeles Quinto, Roland R. Lee
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Hippocampus
Executive Function
0302 clinical medicine
Injury - Trauma - (Head and Spine)
Blast Injuries
Cerebellum
TBI
Prefrontal cortex
Veterans
Cerebral Cortex
MEG
Post-Concussion Syndrome
05 social sciences
Putamen
Magnetoencephalography
Amygdala
inhibition
Military Personnel
medicine.anatomical_structure
Neurological
Biomedical Imaging
Parahippocampal Gyrus
Mental health
Psychology
Adult
Physical Injury - Accidents and Adverse Effects
FC
Traumatic brain injury
1.1 Normal biological development and functioning
Clinical Sciences
Ventromedial prefrontal cortex
Prefrontal Cortex
Traumatic Brain Injury (TBI)
050105 experimental psychology
Temporal lobe
Young Adult
03 medical and health sciences
Underpinning research
Clinical Research
Connectome
medicine
Humans
0501 psychology and cognitive sciences
Traumatic Head and Spine Injury
Brain Concussion
Anterior cingulate cortex
Neurology & Neurosurgery
Resting state fMRI
Neurosciences
excitation
medicine.disease
Brain Waves
United States
Brain Disorders
Dorsolateral prefrontal cortex
blast brain injury
Injury (total) Accidents/Adverse Effects
Neurology (clinical)
Injury - Traumatic brain injury
Neuroscience
Psychomotor Performance
030217 neurology & neurosurgery
Zdroj: Huang, M-X; Harrington, DL; Swan, AR; Quinto, AA; Nichols, S; Drake, A; et al.(2017). Resting-State Magnetoencephalography Reveals Different Patterns of Aberrant Functional Connectivity in Combat-Related Mild Traumatic Brain Injury. JOURNAL OF NEUROTRAUMA, 34(7), 1412-1426. doi: 10.1089/neu.2016.4581. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9xj98969
Journal of neurotrauma, vol 34, iss 7
Popis: Blast mild traumatic brain injury (mTBI) is a leading cause of sustained impairment in military service members and veterans. However, the mechanism of persistent disability is not fully understood. The present study investigated disturbances in brain functioning in mTBI participants using a source-imaging-based approach to analyze functional connectivity (FC) from resting-state magnetoencephalography (rs-MEG). Study participants included 26 active-duty service members or veterans who had blast mTBI with persistent post-concussive symptoms, and 22 healthy control active-duty service members or veterans. The source time courses from regions of interest (ROIs) were used to compute ROI to whole-brain (ROI-global) FC for different frequency bands using two different measures: 1) time-lagged cross-correlation and 2) phase-lock synchrony. Compared with the controls, blast mTBI participants showed increased ROI-global FC in beta, gamma, and low-frequency bands, but not in the alpha band. Sources of abnormally increased FC included the: 1) prefrontal cortex (right ventromedial prefrontal cortex [vmPFC], right rostral anterior cingulate cortex [rACC]), and left ventrolateral and dorsolateral prefrontal cortex; 2) medial temporal lobe (bilateral parahippocampus, hippocampus, and amygdala); and 3) right putamen and cerebellum. In contrast, the blast mTBI group also showed decreased FC of the right frontal pole. Group differences were highly consistent across the two different FC measures. FC of the left ventrolateral prefrontal cortex correlated with executive functioning and processing speed in mTBI participants. Altogether, our findings of increased and decreased regionalpatterns of FC suggest that disturbances in intrinsic brain connectivity may be the result of multiple mechanisms, and are associated with cognitive sequelae of the injury.
Databáze: OpenAIRE
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