Combination Topical Therapy for Conjunctival Primary Acquired Melanosis With Atypia and Periocular Lentigo Maligna
| Autor: | Emily M. Bratton, Siri Knutsen-Larson, Darren G. Gregory, J. Ramsey Mellette, Vikram D. Durairaj |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Conjunctiva Administration Topical medicine.medical_treatment Conjunctival Primary Acquired Melanosis Cryotherapy Imiquimod Lentigo maligna Interferon alpha-2 Eyelid Neoplasms Conjunctival Diseases Melanosis Hutchinson's Melanotic Freckle Antineoplastic Combined Chemotherapy Protocols medicine Atypia Humans Lentigo maligna melanoma Aged 80 and over business.industry Interferon-alpha medicine.disease Combined Modality Therapy Dermatology Recombinant Proteins body regions Ophthalmology medicine.anatomical_structure Aminoquinolines Female sense organs Eyelid business medicine.drug |
| Zdroj: | Cornea. 34:90-93 |
| ISSN: | 0277-3740 |
| Popis: | PURPOSE To report the case of a patient who initially presented with primary acquired melanosis (PAM) without atypia of the conjunctiva and later developed lentigo maligna of the eyelids and PAM with atypia of the conjunctiva. We illustrate the utility of combination topical therapy with adjunctive cryotherapy to treat extensive eyelid and conjunctival lesions. METHODS Case report with a review of the current literature. RESULTS Combination of imiquimod 5% cream (Aldara, 3M Pharmaceuticals) and cryotherapy for periorbital lentigo maligna with topical interferon-α2b for conjunctival PAM with atypia led to clinical resolution of pigmented lesions for 21 months. CONCLUSIONS In our experience, combination topical therapy provides an effective alternative to surgery with superior cosmetic and functional outcomes. |
| Databáze: | OpenAIRE |
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