SERUM INSULIN-LIKE ACTIVITY IN GENETIC AND EXPERIMENTAL DIABETES MELLITUS
| Autor: | Lawrence Power, Jerome W. Conn, Bernardo Reyes-Leal |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Genetics Medical Blood sugar Diabetes Mellitus Experimental Endocrinology Dogs Diabetes mellitus Internal medicine medicine Hyperinsulinemia Diabetes Mellitus Animals Humans Insulin Family history Pancreas Glucose tolerance test medicine.diagnostic_test business.industry Glucose Tolerance Test medicine.disease medicine.anatomical_structure Blood Surgical Procedures Operative Biological Assay business Biomedical sciences |
| Zdroj: | Metabolism: clinical and experimental. 13 |
| ISSN: | 0026-0495 |
| Popis: | A modification of the epididymal fat pad assay for insulin-like activity has been applied to serum from normal subjects, untreated diabetic patients, and dogs with experimentally induced diabetes. Diabetic patients exhibited abnormally elevated serum ILA levels before and after glucose loading, and also demonstrated a delay in their ILA response to glucose. Dogs with experimental diabetes did not show an elevation in their ILA values. Genetically determined diabetes is obviously different from simple insulin deficiency diabetes. The data confirm and extend previous observations that a significant degree of hyperinsulinemia exists in the garden variety of mildly diabetic pa tients. Unusually high levels of insulin like activity were found in 7 of 27 apparently normal subjects. Their ILA exceeded at most times the mean of those found in the diabetic patients. Two of these subjects later discovered a family history of diabetes. Some of the implications of these observations are discussed. |
| Databáze: | OpenAIRE |
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