Mapping of HIV-1C Transmission Networks Reveals Extensive Spread of Viral Lineages Across Villages in Botswana Treatment-as-Prevention Trial
| Autor: | Melissa Zahralban-Steele, Pontiano Kaleebu, Dorcas Maruapula, Myron S. Cohen, Helen Ayles, Janet Seeley, C. E. O. Fraser, Lucie Abeler-Dörner, Deogratius Ssemwanga, Kate Grabowski, Maria J. Wawer, Sarah Fidler, Kara Bennett, Simani Gaseitsiwe, Tapiwa Nkhisang, Thomas C. Quinn, N Paton, Jean Leidner, Mompati Mmalane, Richard J. Hayes, Shahin Lockman, Tanya Golubchik, Andrew J. Leigh-Brown, Ann M Dennis, Etienne Kadima, Sikhulile Moyo, David Bonsall, Andrew Rambaut, Cissy Kityo, Myron Essex, Deenan Pillay, Kathleen E. Wirth, Paul Kellam, Frank Tanser, Anne Hoppe, Vincent Calvez, Unoda Chakalisa, Joshua T. Herbeck, Vlad Novitsky, Joseph Makhema, Dan Frampton, Victor DeGruttola, Mary Fran McLane, Jairam R. Lingappa, Molly Pretorius Holme, Oliver Ratmann, Tendani Gaolathe, Rory Bowden, Joseph Kagaayi, Tulio D’Oliveira |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Adolescent Genotype Maximum likelihood Human immunodeficiency virus (HIV) HIV Infections Genome Viral Biology medicine.disease_cause law.invention Young Adult Major Articles and Brief Reports law Antiretroviral treatment medicine Immunology and Allergy Humans Hiv transmission Phylogeny Botswana Phylogenetic tree Diagnostic Tests Routine virus diseases Middle Aged Treatment as prevention Infectious Diseases Transmission (mechanics) Research Design Antirheumatic Agents HIV-1 Female Combination prevention Sequence Alignment Demography |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 |
| Popis: | Background Phylogenetic mapping of HIV-1 lineages circulating across defined geographical locations is promising for better understanding HIV transmission networks to design optimal prevention interventions. Methods We obtained near full-length HIV-1 genome sequences from people living with HIV (PLWH), including participants on antiretroviral treatment in the Botswana Combination Prevention Project, conducted in 30 Botswana communities in 2013–2018. Phylogenetic relationships among viral sequences were estimated by maximum likelihood. Results We obtained 6078 near full-length HIV-1C genome sequences from 6075 PLWH. We identified 984 phylogenetically distinct HIV-1 lineages (molecular HIV clusters) circulating in Botswana by mid-2018, with 2–27 members per cluster. Of these, dyads accounted for 62%, approximately 32% (n = 316) were found in single communities, and 68% (n = 668) were spread across multiple communities. Men in clusters were approximately 3 years older than women (median age 42 years, vs 39 years; P Conclusions A large number of circulating phylogenetically distinct HIV-1C lineages (molecular HIV clusters) suggests highly diversified HIV transmission networks across Botswana communities by 2018. |
| Databáze: | OpenAIRE |
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