Longitudinal study of Staphylococcus aureus colonization and infection in a cohort of swine veterinarians in the United States
| Autor: | Jeff B. Bender, Douglas Marthaler, My Yang, Peter R. Davies, Srinand Sreevatsan, Jisun Sun, Todd P. Knutson, Randall S. Singer |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
DNA Bacterial Methicillin-Resistant Staphylococcus aureus Veterinary medicine medicine.medical_specialty Staphylococcus aureus Swine 030106 microbiology Population MRSA medicine.disease_cause Staphylococcal infections lcsh:Infectious and parasitic diseases Veterinarians 03 medical and health sciences Medical microbiology medicine Prevalence Animals Humans lcsh:RC109-216 Colonization Longitudinal Studies education 2. Zero hunger Swine Diseases education.field_of_study Whole Genome Sequencing business.industry Staphylococcal Infections medicine.disease Persistent carriage Methicillin-resistant Staphylococcus aureus United States 3. Good health Infectious Diseases Carriage Cohort Nasal Cavity business Multilocus Sequence Typing Research Article |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-13 (2017) |
| ISSN: | 1471-2334 |
| Popis: | Background People working with pigs are at elevated risk of harboring methicillin resistant S. aureus (MRSA) in their nose, which is attributable to occupational exposure to animals harboring livestock adapted S. aureus. To obtain insight into the biological nature of occupationally related nasal culture positivity, we conducted a longitudinal study of 66 swine veterinarians in the USA. Methods The study cohort resided in 15 US states and worked predominantly with swine. Monthly for 18 months, participants self-collected nasal swabs and completed a survey to report recent exposure to pigs and other animals; the occurrence of work related injuries; and any relevant health events such as skin and soft tissue infections or confirmed staphylococcal infections. Nasal swabs were cultured using selective methods to determine the presence of MRSA and methicillin susceptible S. aureus (MSSA), and isolates were characterized by spa typing and MLST. Results Prevalences of S. aureus (64%, monthly range from 58 to 82%) and MRSA (9.5%; monthly range from 6 to15%) were higher than reported for the US population (30% and 1.5% respectively). Predominant spa types were t034 (ST398, 37%), t002 (ST5, 17%) and t337 (ST9/ST398 13%), a distribution similar to that found in a concurrent study in pigs in the USA. Veterinarians were classified into three groups: Persistent carriers (PC, 52%), Intermittent carriers (IC, 47%) and Non-carriers (NC, 1%). Persistent carriage of a single spa type was observed in 14 (21%) of participants, and paired (first and last) isolates from PC subjects had minor genetic differences. Swabs from PC veterinarians carried higher numbers of S. aureus. Among IC veterinarians, culture positivity was significantly associated with recent contact with pigs. Conclusions Exposure to pigs did not lead to prolonged colonization in most subjects, and the higher numbers of S. aureus in PC subjects suggests that unknown host factors may determine the likelihood of prolonged colonization by S. aureus of livestock origin. Exposure to S. aureus and persistent colonization of swine veterinarians was common but rarely associated with S. aureus disease. Electronic supplementary material The online version of this article (10.1186/s12879-017-2802-1) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink