Evaluation of baseline structural factors for predicting glaucomatous visual-field progression using optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy
| Autor: | Mitra Sehi, David S. Greenfield, Namita Bhardwaj, Yun S. Chung |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Materials science genetic structures Scanning laser polarimetry Glaucoma law.invention Ophthalmoscopy Optical coherence tomography law medicine Humans Prospective Studies Intraocular Pressure Aged medicine.diagnostic_test Lasers Follow up studies Reproducibility of Results Optic Nerve Middle Aged medicine.disease Laser eye diseases Visual field Confocal scanning laser ophthalmoscopy Ophthalmology Scanning Laser Polarimetry Clinical Study Disease Progression Visual Field Tests Optometry Female Visual Fields Tomography Optical Coherence Follow-Up Studies Biomedical engineering |
| Zdroj: | Eye. 26:1527-1535 |
| ISSN: | 1476-5454 0950-222X |
| DOI: | 10.1038/eye.2012.203 |
| Popis: | The objective of this study is to assess whether baseline optic nerve head (ONH) topography and retinal nerve fiber layer thickness (RNFLT) are predictive of glaucomatous visual-field progression in glaucoma suspect (GS) and glaucomatous eyes, and to calculate the level of risk associated with each of these parameters.Participants with ≥28 months of follow-up were recruited from the longitudinal Advanced Imaging for Glaucoma Study. All eyes underwent standard automated perimetry (SAP), confocal scanning laser ophthalmoscopy (CSLO), time-domain optical coherence tomography (TDOCT), and scanning laser polarimetry using enhanced corneal compensation (SLPECC) every 6 months. Visual-field progression was assessed using pointwise linear-regression analysis of SAP sensitivity values (progressor) and defined as significant sensitivity loss of1 dB/year at ≥2 adjacent test locations in the same hemifield at P0.01. Cox proportional hazard ratios (HR) were calculated to determine the predictive ability of baseline ONH and RNFL parameters for SAP progression using univariate and multivariate models.Seventy-three eyes of 73 patients (43 GS and 30 glaucoma, mean age 63.2±9.5 years) were enrolled (mean follow-up 51.5±11.3 months). Four of 43 GS (9.3%) and 6 of 30 (20%) glaucomatous eyes demonstrated progression. Mean time to progression was 50.8±11.4 months. Using multivariate models, abnormal CSLO temporal-inferior Moorfields classification (HR=3.76, 95% confidence interval (CI): 1.02-6.80, P=0.04), SLPECC inferior RNFLT (per -1 μm, HR=1.38, 95% CI: 1.02-2.2, P=0.02), and TDOCT inferior RNFLT (per -1 μm, HR=1.11, 95% CI: 1.04-1.2, P=0.001) had significant HRs for SAP progression.Abnormal baseline ONH topography and reduced inferior RNFL are predictive of SAP progression in GS and glaucomatous eyes. |
| Databáze: | OpenAIRE |
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