The Role of Thyroid Hormones in Prenatal and Neonatal Neurological Development—Current Perspectives
| Autor: | Chester E. Hendrich, Susan P. Porterfield |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Thyroid Hormones
medicine.medical_specialty Placenta Endocrinology Diabetes and Metabolism Central nervous system Thyroid Gland Physiology Prenatal care Embryonic and Fetal Development Animal data Endocrinology Pregnancy Internal medicine medicine Animals Humans Maternal-Fetal Exchange Fetus business.industry Thyroid Brain medicine.disease Iodine deficiency Rats medicine.anatomical_structure Animals Newborn Thyroid hormones Female business Iodine |
| Zdroj: | Endocrine Reviews. 14:94-106 |
| ISSN: | 1945-7189 0163-769X |
| Popis: | I. Introduction FOR YEARS thyroid hormones have been known to be important for normal neonatal brain development, and numerous reviews have covered this topic in depth. It now also appears that fetal thyroid hormones play an essential role in fetal brain development. In addition, as some placental transport of thyroid hormones has been shown to occur, it is possible that maternal thyroid hormones might influence fetal brain development. II. The Value of the Use of Animal Models in the Comprehension of the Role of Thyroid Hormones in Neurological Development Animal models have been used to study the influence of thyroid hormones on neurological] evelopment. Rats and mice have been the primary animals studied; however, a significant amount of data have come from studies on sheep and nonhuman primates. While the merit of application of animal data to human problems is frequently questioned, valuable information can be obtained when the animal data are properly interpreted. Furthermore, most of the informatio... |
| Databáze: | OpenAIRE |
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