Peri-pubertal high caffeine exposure increases ovarian estradiol production in immature rats
| Autor: | Jaeman Bae, Yun Young Choi, Hyeonhae Choi, Yoojin Kwak, Jaesook Roh |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class Uterus Estrogen receptor Ovary Toxicology Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Aromatase 0302 clinical medicine Caffeine 030225 pediatrics Internal medicine medicine Animals Sexual maturity Sexual Maturation Estradiol biology Body Weight Estradiol secretion 030104 developmental biology medicine.anatomical_structure Endocrinology Adipose Tissue chemistry Estrogen biology.protein Female |
| Zdroj: | Reproductive Toxicology. 69:43-52 |
| ISSN: | 0890-6238 |
| Popis: | Chronic caffeine consumption exerts a negligible effect on the reproductive organs of normal adult females, but it is not known whether this is also true for children and adolescents. Here, we investigated the effects of high caffeine exposure on sexual maturation and ovarian estradiol production in immature female rats. Immature female SD rats were divided into controls and caffeine groups fed 120 and 180mg/kg/day for 4 or 8 weeks. There was a significant delay in vaginal opening in the caffeine-fed groups. In addition, serum estradiol levels were elevated in the caffeine-fed animals after 2 and 4 weeks of exposure. Estradiol secretion as well as aromatase expression also increased significantly in the ovarian cells in response to caffeine. These results demonstrate that peripubertal exposure to high caffeine increases estradiol production in the ovary; this may disturb the coordinated regulation of the hypothalamo-pituitary-ovarian axis, thereby interfering with sexual maturation. |
| Databáze: | OpenAIRE |
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