Vaccine design and delivery approaches for COVID-19

Autor: Shaghayegh Haghjooy Javanmard, Abbas Alibakhshi, Elmira Mohammadi, Sahar Esfandyari, Leila Beikmohammadi, Samira Bahrami, Mohammad Mehdi Ranjbar, Shahrzad Ahangarzadeh, Fatemeh Mahmoudian, Kiana Shahzamani
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Vaccine delivery
SARS-CoV-2
Severe Acute Respiratory Syndrome Coronavirus-2

APC
Antigen-Presenting Cell

S.C.
Subcutaneous

MERS
Middle East Respiratory Syndrome

RSV
Respiratory Syncytial Virus

Disease
SAGE
Strategic Advisory Group of Experts on Immunization

Health Services Accessibility
Delivery methods
Immunology and Allergy
Drug Approval
Vaccine design
CDC
Centers for Disease Control and Prevention

PAMP
Pathogen-Associated Molecular Pattern

LNP
Lipid Nanoparticles

Vaccination
LMH
Live Modified Horsepox

Chimpanzee Adenoviral Vector 1
ChAdOx1

Ad
Adenovirus

GMV
Genetically Modified Viruses

TLR
Toll-Like Receptor

EUA
Emergency Use Authorization

ACE2
Angiotensin Converting Enzyme 2
Coalition for Epidemic Preparedness Innovations

medicine.medical_specialty
2019-20 coronavirus outbreak
COVID-19 Vaccines
Coronavirus disease 2019 (COVID-19)
I.M.
Intramuscular

Emerging technologies
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
VRP
Virion Replicon Particle

Immunology
ASHP
American Society of Health-System Pharmacists

Article
SDG 3 - Good Health and Well-being
medicine
Humans
Intensive care medicine
LAV
Live-Attenuated Virus

Disease burden
Pharmacology
VLP
Virus-Like Particle

SARS-CoV-2
COVID-19
Coronavirus Disease-19

business.industry
COVID-19
RBD
Receptor Binding Domain

PRR
Pattern Recognition Receptors

MVA
Modified Vaccinia Ankara

VEE
Venezuelan Equine Encephalitis

Nanoparticles
business
Vaccine
WCA
Whole-Cell Antigen
Zdroj: International Immunopharmacology
ISSN: 1567-5769
Popis: COVID-19 is still a deadly disease that remains yet a major challenge for humans. In recent times, many large pharmaceutical and non-pharmaceutical companies have invested a lot of time and cost in fighting this disease. In this regard, today's scientific knowledge shows that designing and producing an effective vaccine is the best possible way to diminish the disease burden and dissemination or even eradicate the disease. Due to the urgent need, many vaccines are now available earlier than scheduled. New technologies have also helped to produce much more effective vaccines, although the potential side effects must be taken into account. Thus, in this review, the types of vaccines and vaccine designs made against COVID-19, the vaccination programs, as well as the delivery methods and molecules that have been used to deliver some vaccines that need a carrier will be described.
Databáze: OpenAIRE