Methamphetamine protects against stress-induced gastric mucosal lesions in mice
| Autor: | Masayuki Nata, Takemi Otsuki, Hideo Ishizu, Fumio Moriya, Toshiko Okuyama, Hironobu Katsuyama, Yoko Watanabe, Kazuo Hidaka, Masafumi Tomita |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Methamphetamine Pathology and Forensic Medicine Mice chemistry.chemical_compound Stress Physiological Corticosterone Internal medicine Immersion medicine Animals business.industry Stress induced Mucosal lesions Normal group Mice Inbred C57BL Issues ethics and legal aspects Cytokine Endocrinology chemistry Gastric Mucosa Immunology Cytokines Central Nervous System Stimulants Tumor necrosis factor alpha Restraint stress Gastrointestinal Hemorrhage business medicine.drug |
| Zdroj: | Legal Medicine. 11:S437-S439 |
| ISSN: | 1344-6223 |
| DOI: | 10.1016/j.legalmed.2009.01.020 |
| Popis: | Stress-induced gastric mucosal injury is a common clinical entity. On the other hand, abuse of methamphetamine (MA) represents a growing social problem. MA users are frequently in stressful situations. In this study, we examined the effects of MA on gastric injury, corticosterone level and immunomodulation using a water-immersion restraint stress (WRS) mouse model that is well known to induce gastric lesions. Mice were randomly divided into five groups: (1) the normal group, (2) the 3 hour (3 h)-WRS group, (3) the 6 hour (6 h)-WRS group, (4) the MA (3 mg/kg) plus 6 h-WRS group and (5) the MA (30 mg/kg) plus 6h-WRS group. As expected, most animals examined (above 90%) showed gastric injury after the WRS exposure. However, administration of MA at both 3 and 30 mg/kg resulted in significant suppression of the injury. The corticosterone levels were increased by exposure to the stress and/or MA, but there was no difference between these groups. The levels of the serum cytokines IL-6, IL-10 and TNF were increased by WRS, and were markedly increased by MA plus WRS; in particular, the level of IL-6 was synergistically increased. On the contrary, the level of IL-1beta was significantly decreased by WRS and MA plus WRS. This is the first report showing the protective effect of MA on stress-induced gastric injury, although further study is necessary to resolve the mechanism of MA-driven suppression of the injury. |
| Databáze: | OpenAIRE |
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