Effect of harmane on mononeuropathic pain in rats
| Autor: | Eylem Korcegez, Feyza Aricioglu, Süleyman Özyalçin |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Imidazoline receptor
Pain General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Harmine History and Philosophy of Science medicine Animals Harmane Rats Wistar Pain Measurement Dose-Response Relationship Drug Chemistry General Neuroscience Thermal Allodynia Sciatic Nerve Rats Cold Temperature Dose–response relationship Allodynia Anesthesia Neuropathic pain Sciatic nerve medicine.symptom Carbolines |
| Zdroj: | Annals of the New York Academy of Sciences. 1009 |
| ISSN: | 0077-8923 |
| Popis: | This study was designed to investigate the effect of the endogenous beta-carboline, harmane, on neuropathic pain produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal allodynia evaluations were made preoperatively, postoperatively on the fifteenth day, and after harmane administration. Harmane (1, 2.5, 5, 10, or 20 mg/kg) was administered intraperitoneally for 5 days beginning from postoperative day 15. Treatment with harmane had a profound anti-allodynic effect in a dose-dependent manner. In conclusion, harmane might provide a new approach to treatment of neuropathic pain. |
| Databáze: | OpenAIRE |
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