The resistance of the wistar/furth rat strain to steroid hypertension
| Autor: | Kathleen Kayes, Lynn Ziegler, Cheng-Ping Yu, Alexander C. Brownie, Samuel Gallant |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty ATPase Gene Expression Rats Inbred WF Pharmacology Dexamethasone chemistry.chemical_compound Receptors Glucocorticoid Endocrinology Glucocorticoid receptor Mineralocorticoid receptor Mineralocorticoids Internal medicine Renin Renin–angiotensin system medicine Animals RNA Messenger Desoxycorticosterone Aldosterone Mineralocorticoid Receptor Antagonists Adenosine Triphosphatases biology business.industry Antagonist General Medicine Rats Receptors Mineralocorticoid chemistry Hypertension biology.protein business ATP synthase alpha/beta subunits medicine.drug |
| Zdroj: | Endocrine Research. 22:681-689 |
| ISSN: | 1532-4206 0743-5800 |
| Popis: | We have previously reported that the Wistar/Furth (W/Fu) rat strain is resistant to mineralocorticoid hypertension. In the current study, we have examined renal mRNA levels for mineralocorticoid receptor (MR), glucocorticoid receptor (GR), renin and Na+, K(+)-ATPase in response to treatment with mineralocorticoids. Uninephrectomized male Wistar (WI) and W/Fu rats were treated with aldosterone or deoxycorticosterone acetate (DOCA) and were given 1% NaCl to drink. Rats were sacrificed after 1, 3 or 7 days of treatment. Renal MR and ATPase mRNA levels were significantly reduced in aldosterone and DOCA-treated WI rats (e.g. MR was 30% on day 3 and ATPase was 50% of control on day 7 of aldosterone treatment). Unexpectedly, GR mRNA levels paralleled the changes in MR. In W/Fu rats the level of message was either unchanged or only moderately altered by this treatment. In vivo administration of the MR antagonist RU28318 or the GR antagonist RU38486 to WI rats for 4 days reduced renal mRNA levels for both subunits of ATPase. In the W/Fu rat, this treatment resulted in no change in the alpha subunit and an increase in the beta subunit of ATPase. In preliminary studies, we have determined that the W/Fu rat is also resistant to dexamethasone-induced hypertension. These studies suggest that altered MR- and GR-mediated mechanisms may contribute to the resistance of the W/Fu rat strain to steroid-induced hypertension. |
| Databáze: | OpenAIRE |
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