CLINICAL COURSE AND MANAGEMENT OF INFLAMMATORY BOWEL DISEASE AFTER LIVER TRANSPLANTATION
| Autor: | K A Newell, K. Dasgupta, H Conjeevaram, J M Millis, J. R. Thistlethwaite, Alfred L. Baker, Thomas D. Schiano, Trevor Lissoos, Alex S. Befeler |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Cholangitis Sclerosing Azathioprine Liver transplantation Gastroenterology Inflammatory bowel disease Primary sclerosing cholangitis Postoperative Complications Crohn Disease Prednisone Internal medicine medicine Humans Colectomy Retrospective Studies Transplantation business.industry Inflammatory Bowel Diseases medicine.disease Ulcerative colitis digestive system diseases Liver Transplantation Aminosalicylic Acids surgical procedures operative Colitis Ulcerative business Immunosuppressive Agents medicine.drug |
| Zdroj: | Transplantation. 65:393-396 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-199802150-00017 |
| Popis: | Background Previous reports investigating the clinical course and management of inflammatory bowel disease (IBD) after orthotopic liver transplant (OLT) have revealed conflicting results. Methods To determine the natural history and course of therapy for liver transplant patients with IBD, we reviewed the records of 35 patients, who underwent OLT between 1985 and 1996 and who had a history of either IBD (29 patients) or primary sclerosing cholangitis (PSC) without evidence of IBD before OLT (6 patients). Of 29 patients with IBD before OLT, 25 had a history of ulcerative colitis (UC) and 4 had Crohn's disease. Six patients had undergone total colectomy, one subtotal colectomy, and three partial colectomy before OLT. Mean follow-up after OLT was 37+/-6.4 months. Immunosuppression included cyclosporine, prednisone, and azathioprine in 34 patients and tacrolimus and prednisone in 1 patient. Results After OLT, 17 patients (49%) had quiescent disease and were receiving no additional medications other than standard immunosuppression to prevent organ rejection. Five patients (14%) had mild flares controlled with initiation of 5'-aminosalicylates (5'-ASA), and two patients (6%) required an increase in oral prednisone. Only one patient with PSC, without evidence of IBD before OLT, developed IBD after OLT. No patients required intravenous steroids or surgical intervention for active IBD. Conclusions (1) Standard postOLT immunosuppressive agents in patients undergoing OLT with IBD were able to adequately control disease activity after OLT in the majority of patients. (2) IBD flares after OLT were generally well controlled with aminosalicylates or oral steroids. (3) Aminosalicylates were helpful in the clinical management of IBD, even when patients were taking standard doses of steroids, azathioprine, and cyclosporine. |
| Databáze: | OpenAIRE |
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