Lupeol Isolated from Sorbus commixta Suppresses 1α,25-(OH)2D3-Mediated Osteoclast Differentiation and Bone Loss in Vitro and in Vivo
| Autor: | Dong-Sung Lee, Seong-Ryong Lee, Nam Kyung Im, Gil Saeng Jeong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Osteolysis Pharmaceutical Science Osteoclasts Pharmacology Biology Bone resorption Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine In vivo Osteoclast Internal medicine Drug Discovery medicine Animals Sorbus Bone Resorption Vitamin D Lupeol Sorbus commixta Molecular Structure Organic Chemistry RANK Ligand NF-kappa B biology.organism_classification medicine.disease In vitro Disease Models Animal 030104 developmental biology Endocrinology medicine.anatomical_structure Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis Molecular Medicine Mitogen-Activated Protein Kinases Pentacyclic Triterpenes Proto-Oncogene Proteins c-fos |
| Zdroj: | Journal of natural products. 79(2) |
| ISSN: | 1520-6025 |
| Popis: | Lupeol is a lupane-type triterpene isolated from Sorbus commixta, an oriental medicine used to treat arthritis and inflammatory diseases. However, the antiosteoporotic effects of S. commixta or any of its constituents have not been studied yet. In the present study, we have examined the effect of lupeol (a major active triterpenoid isolated from S. commixta) on osteoclastogenesis and sought to elucidate its underlying molecular mechanisms. We evaluated whether lupeol antagonized osteoclast differentiation and bone resorption. Lupeol markedly inhibited osteoclast differentiation and bone resorption activity through its effects on MAP kinases and transcription factors (NF-κB, NFATc1, and c-Fos) downstream of the osteoclast differentiation factor receptor RANK. Furthermore, in vivo efficacy of lupeol was confirmed by using an animal model of hypercalcemic mediated bone loss. Taken together, lupeol showed strong inhibitory effects on osteoclastogenesis. Supplementation with S. commixta and lupeol could be beneficial for bone health or osteoclast-related diseases such as osteoporosis, Paget's disease, osteolysis associated with periodontal disease, and multiple myeloma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|