Effects of Growing-Up Milk Supplemented With Prebiotics and LCPUFAs on Infections in Young Children
| Autor: | Patricia Logtens-de Graaff, Nipat Simakachorn, Hania Szajewska, Way S. Lee, Eugenia Carrilho, Bastiaan Schouten, Yalcin Yavuz, Pantipa Chatchatee, Pensri Kosuwon |
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| Rok vydání: | 2014 |
| Předmět: |
Diarrhea
Male medicine.medical_specialty Pediatrics Fever Vomiting Oligosaccharides Fructose Infections Logistic regression n-3 LCPUFAs Body Mass Index law.invention Double-Blind Method Randomized controlled trial law Internal medicine Statistical significance Fatty Acids Omega-3 medicine Animals Humans Respiratory Tract Infections growing-up milk young children chemistry.chemical_classification Respiratory tract infections business.industry Body Weight Gastroenterology Galactose Infant Original Articles: Hepatology and Nutrition Body Height infection Confidence interval Milk Prebiotics chemistry Child Preschool Relative risk Dietary Supplements Pediatrics Perinatology and Child Health Female business Body mass index scGOS/lcFOS Polyunsaturated fatty acid |
| Zdroj: | Journal of Pediatric Gastroenterology and Nutrition |
| ISSN: | 0277-2116 |
| Popis: | Objective: The aim of this study was to investigate the effect of growing-up milk (GUM) with added short-chain galacto-oligosaccharides (scGOS)/long-chain fructo-oligosaccharides (lcFOS) (9:1) (Immunofortis) and n-3 long-chain polyunsaturated fatty acids (LCPUFAs) on the occurrence of infections in healthy children attending day care centres. Methods: In a randomised double-blind controlled, parallel, multicountry intervention study, 767 healthy children, ages 11 to 29 months, received GUM with scGOS/lcFOS/LCPUFAs (the active group, n = 388), GUM without scGOS/lcFOS/LCPUFAs (the control group, n = 379), or cow's milk (n = 37) for 52 weeks. The primary outcome measure was the number of episodes of upper respiratory tract infections or gastrointestinal infections based on a combination of subject's illness symptoms reported by the parents during the intervention period. Results: Children in the active group compared with the control group had a decreased risk of developing at least 1 infection (299/388 [77%] vs 313/379 [83%], respectively, relative risk 0.93, 95% confidence interval [CI] 0.87–1.00; logistic regression P = 0.03). There was a trend toward a reduction (P = 0.07) in the total number of infections in the active group, which was significant when confirmed by one of the investigators (268/388 [69%] vs 293/379 [77%], respectively, relative risk 0.89, 95% CI 0.82–0.97; P = 0.004, post hoc). More infectious episodes were observed in the cow's milk group, when compared with both GUM groups (34/37 [92%] vs 612/767 [80%], respectively, relative risk 1.15, 95% CI 1.04–1.28). Conclusions: This is the first study in children to show a reduced risk of infection following consumption of GUM supplemented with scGOS/lcFOS/n-3 LCPUFAs. The borderline statistical significance justifies a new study to confirm this finding. |
| Databáze: | OpenAIRE |
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