Synthesis and in vivo evaluation of a scaffold containing wollastonite/β-TCP for bone repair in a rabbit tibial defect model
| Autor: | Willams Teles Barbosa, Miguel A. Rodríguez, Katilayne Vieira de Almeida, Marcos V Lia Fook, Francisco Alipio de Sousa Segundo, Gabriel Goetten de Lima, Raúl García-Carrodeguas, Marcelo Jorge Cavalcanti de Sá, Valdemiro Amaro da Silva Junior |
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| Rok vydání: | 2019 |
| Předmět: |
Calcium Phosphates
Male Ceramics Materials science Bone Regeneration Biocompatibility Polymers Radiodensity Biomedical Engineering chemistry.chemical_element Biocompatible Materials 02 engineering and technology Bone healing Calcium 010402 general chemistry Bone tissue 01 natural sciences Biomaterials chemistry.chemical_compound X-Ray Diffraction Materials Testing medicine Animals Particle Size Bone regeneration Tibia Tissue Engineering Tissue Scaffolds Silicates Calcium Compounds 021001 nanoscience & nanotechnology 0104 chemical sciences medicine.anatomical_structure chemistry Calcium silicate Bone Substitutes Microscopy Electron Scanning Female Implant Rabbits Powders 0210 nano-technology Biomedical engineering |
| Zdroj: | Journal of biomedical materials research. Part B, Applied biomaterialsREFERENCES. 108(3) |
| ISSN: | 1552-4981 |
| Popis: | Scaffolds are models designed to aid the interaction between cells and extracellular bone matrix, providing structural support for newly formed bone tissue. In this work, wollastonite with β-TCP porous ceramic scaffolds was developed by the polymer sponge replication. Their microstructure, cell viability and bioactivity were tested. in vivo was performed to evaluate the use of a calcium silicate-based implant in the repair of rabbit tibias. Holes were made in the both proximal and distal tibial metaphysis of each animal and filled with calcium silicate-based implant, and in the left tibia, no implant were used, serving as control group. Animals underwent euthanasia after 30 and 60 days of study. The animals were submitted to clinical-radiographic evaluations and their histology was analyzed by optical and scanning electron microscope. The studied calcium silicate implant provided biocompatibility and promoted bone formation, stimulating the process of bone repair in rabbits, features observed by gradual radiopacity shown in the radiographic evaluations. |
| Databáze: | OpenAIRE |
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