Opposite effects of cannabis and cocaine on performance monitoring
| Autor: | Robbert J. Verkes, Roshan Cools, Desirée Spronk, Ellen R.A. de Bruijn, Barbara Franke, Johannes G. Ramaekers, Janelle H. P. van Wel |
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| Přispěvatelé: | Section Psychopharmacology, RS: FPN NPPP II |
| Rok vydání: | 2016 |
| Předmět: |
Male
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Poison control Neuropsychological Tests Electroencephalography Audiology Executive Function 0302 clinical medicine Dopamine Uptake Inhibitors Cocaine Pharmacology (medical) BRAIN Evoked Potentials media_common Cross-Over Studies biology medicine.diagnostic_test 05 social sciences Psychiatry and Mental health Neurology Error positivity Female Psychology Drug medicine.medical_specialty SEX-DIFFERENCES Substance-Related Disorders Error-related negative media_common.quotation_subject EVENT-RELATED POTENTIALS SELECTIVE ATTENTION behavioral disciplines and activities 050105 experimental psychology Error-related negativity Young Adult 03 medical and health sciences Double-Blind Method RESPONSE CONFLICT medicine Humans ANTISACCADE TASK 0501 psychology and cognitive sciences INHIBITORY CONTROL Psychiatry ERROR Biological Psychiatry Effects of cannabis Cannabis Pharmacology Psychotropic Drugs Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] COMPONENTS biology.organism_classification Crossover study Performance monitoring Neurology (clinical) Antisaccade task 170 000 Motivational & Cognitive Control 030217 neurology & neurosurgery HEALTHY-VOLUNTEERS |
| Zdroj: | European Neuropsychopharmacology, 26, 7, pp. 1127-39 European Neuropsychopharmacology, 26(7). Elsevier European Neuropsychopharmacology, 26, 1127-39 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/j.euroneuro.2016.03.015 |
| Popis: | Contains fulltext : 167100.pdf (Publisher’s version ) (Closed access) Drug use is often associated with risky and unsafe behavior. However, the acute effects of cocaine and cannabis on performance monitoring processes have not been systematically investigated. The aim of the current study was to investigate how administration of these drugs alters performance monitoring processes, as reflected in the error-related negativity (ERN), the error positivity (Pe) and post-error slowing. A double-blind placebo-controlled randomized three-way crossover design was used. Sixty-one subjects completed a Flanker task while EEG measures were obtained. Subjects showed diminished ERN and Pe amplitudes after cannabis administration and increased ERN and Pe amplitudes after administration of cocaine. Neither drug affected post-error slowing. These results demonstrate diametrically opposing effects on the early and late phases of performance monitoring of the two most commonly used illicit drugs of abuse. Conversely, the behavioral adaptation phase of performance monitoring remained unaltered by the drugs. |
| Databáze: | OpenAIRE |
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