Respiratory Disease Markers in Porcine Bronchoalveolar Lavage Fluid
| Autor: | Martin Ganter, K.-H. Waldmann, Martin Beyerbach, Jutta Verspohl, Frank Blecha, K. Strutzberg-Minder, S. Bremerich, Isabel Hennig-Pauka, C. Schröder, H. Nienhoff, G. F. Gerlach |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Neutrophils Swine animal diseases Respiratory tract disease medicine.disease_cause Bronchoalveolar Lavage Pathology and Forensic Medicine Leukocyte Count Predictive Value of Tests Bronchoscopy Medicine Animals Respiratory Tract Infections Respiratory health Swine Diseases General Veterinary medicine.diagnostic_test biology business.industry Respiratory disease Pathogenic bacteria respiratory system biology.organism_classification medicine.disease Antibacterial peptide respiratory tract diseases Bronchoalveolar lavage Immunology Herd Female Clinical Medicine business Bronchoalveolar Lavage Fluid Bacteria Antimicrobial Cationic Peptides |
| Zdroj: | Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine |
| ISSN: | 1439-0442 0931-184X |
| Popis: | Summary In bronchoalveolar lavage fluid (BALF) of pigs originating from different herds bacteria, cells and the antibacterial peptide PR‐39 were examined to gain information about the lung health status. In a high health nucleus herd 56% and in low health herds 20–100% of the examined pigs were found positive for potentially pathogenic bacteria. Based on these findings, a novel definition for bacterial respiratory tract disease was established using an 8% cut‐off for the relative number of neutrophils in bronchoscopic and a 40% cut‐off in transtracheal BALF in combination with the occurrence of potentially pathogenic microorganisms. The antibacterial peptide PR‐39 was highly correlated to this definition of respiratory disease. An assessment of the bacteriological respiratory health status appears to be possibly based on the determination of PR‐39 concentrations in BALF using different cut‐off values according to the lavage method (2.5 nM for bronchoscopic and 5 nM for transtracheal BALF). |
| Databáze: | OpenAIRE |
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