Role of Intracystic Cytokines and Nitric Oxide in Ovarian Neoplasms

Autor:	M. P. Jammal, Douglas Côbo Micheli, R. M. Etchebehere, Beatriz Martins Tavares-Murta, A. Martins-Filho, E. F. C. Murta, R. S. Nomelini
Rok vydání:	2017
Předmět:	Adult 0301 basic medicine Pathology medicine.medical_specialty Necrosis Adolescent Carcinogenesis Lymphocyte medicine.medical_treatment Immunology Nitric Oxide Gastroenterology Nitric oxide Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans Child Survival analysis Aged Aged 80 and over Ovarian Neoplasms Interleukin-6 business.industry Interleukin-8 Ovary Interleukin General Medicine Middle Aged medicine.disease Survival Analysis Ovarian Cysts 030104 developmental biology medicine.anatomical_structure Cytokine chemistry 030220 oncology & carcinogenesis Female Tumor necrosis factor alpha medicine.symptom Ovarian cancer business
Zdroj:	Scandinavian Journal of Immunology. 86:462-470
ISSN:	0300-9475
DOI:	10.1111/sji.12617
Popis:	The development of new biomarkers for the diagnosis and prognosis of ovarian cancer may provide an opportunity for new therapies. In this study, we aimed to compare cytokines (interleukin [IL]-2, IL-5, IL-6, IL-8, IL-10 and tumour necrosis factor [TNF]-α) and nitric oxide (NO) metabolite levels in non-neoplastic tumours, benign primary ovarian tumours and malignant primary ovarian neoplasms. The secondary aim was to relate cytokine and intracystic NO metabolite levels to clinical, laboratory and pathologic characteristics for patients with primary ovarian malignancies. We evaluated 110 patients with adnexal masses. Cytokine concentrations were quantified by enzyme-linked immunosorbent assay and nitrate concentrations by enzymatic reduction of nitrite by nitrate reductase. Patients with malignant neoplasms had higher IL-6, IL-8 and NO levels compared to patients with benign neoplasms. Histologic grade 1 tumours were associated with elevated IL-2 levels, whereas anaemia was associated with elevated IL-6 levels. On average, those patients with elevated IL-8 levels also had a neutrophil/lymphocyte ratio (NLR) greater than 2.6 and less than 36 months of disease-free survival (DFS). Patients with normal CA 19-9 levels had elevated IL-10 levels. TNF-α was elevated in patients with two carcinogenesis and those with a platelet/lymphocyte ratio (PLR) less than 300. NO levels were higher in patients with an NLR less than 2.6 and CA 19-9 greater than 35 U/ml. Elevated intracystic cytokine levels, especially IL-6 and IL-8, are associated with worse prognosis in ovarian cancer.
Databáze:	OpenAIRE
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