Dehydroepiandrosterone and cortisol/dehydroepiandrosterone ratios in dairy cattle with postpartum metritis
| Autor: | Marion Schmicke, Marcelo Gil, Martina Hoedemaker, Neele Hendrika Gundlach, Yasmin Gundelach, Ursula Siebert, M. Feldmann |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty Hydrocortisone Dehydroepiandrosterone Ice calving Cattle Diseases Reference range 03 medical and health sciences chemistry.chemical_compound Internal medicine polycyclic compounds medicine Leukocytes Animals Metritis skin and connective tissue diseases Dairy cattle General Veterinary Adrenal cortex business.industry Antiglucocorticoid Postpartum Period 0402 animal and dairy science 04 agricultural and veterinary sciences medicine.disease 040201 dairy & animal science 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Cattle Female Endometritis business human activities hormones hormone substitutes and hormone antagonists |
| Zdroj: | Research in veterinary science. 115 |
| ISSN: | 1532-2661 |
| Popis: | Dehydroepiandrosterone (DHEA), a C19 steroid synthesized predominantly by the adrenal cortex, and its sulfated precursor (DHEAS) has antiglucocorticoid and immunoprotective properties. DHEA is important in modulating inflammatory responses; therefore, we hypothesized that DHEA concentrations might be altered in bovine postpartum metritis. DHEA, DHEAS, the cortisol/DHEA-ratio (C/D-ratio) and the DHEAS/DHEA ratio were determined in cows with and without clinical metritis subcategorized by the blood leukocyte numbers. Blood from the coccygeal vein of 37 pluriparous Holstein-Friesian cows was sampled 8.8 ± 0.9 days (mean ± SE) after calving. Based on clinical signs of metritis and leukocyte numbers (normal range 5–10 × 106/μl), cows were classified as healthy with leukocyte numbers in the reference range (leukocyte normal; LNH = 5954.17 ± 302.4/μl); suffering from metritis with normal leukocyte counts (LNM = 7422.22 ± 774.74/μl); or metritis with leukopenia (LLM = 3950 ± 284.31/μl P |
| Databáze: | OpenAIRE |
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