Endothelial Dysfunction is Related to Glycemic Variability and Quality and Duration of Sleep in Adults With Type 1 Diabetes
| Autor: | Lauretta Quinn, Dan V. Mihailescu, Chang Gi Park, Shane A. Phillips, Sarah S. Farabi, Pamela Martyn-Nemeth, Mohammed Ali |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Brachial Artery Endothelium Cross-sectional study Vasodilator Agents Population 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Pittsburgh Sleep Quality Index Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine Humans Endothelial dysfunction education Ultrasonography Glycemic Glycated Hemoglobin Advanced and Specialized Nursing education.field_of_study Type 1 diabetes business.industry medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 1 medicine.anatomical_structure Cardiology Female Endothelium Vascular Sleep Cardiology and Cardiovascular Medicine business Blood Flow Velocity |
| Zdroj: | Journal of Cardiovascular Nursing. 33:E21-E25 |
| ISSN: | 1550-5049 0889-4655 |
| DOI: | 10.1097/jcn.0000000000000485 |
| Popis: | Background Elevated cardiovascular disease risk in people with type 1 diabetes (T1DM) is incompletely understood. Glycemic control, glycemic variability, and sleep quality and duration may relate to cardiovascular disease risk in this population via endothelial dysfunction. Objective The aim of this study was to examine relationships among glycemic control, glycemic variability, sleep quality and duration, and endothelial function in adults with T1DM. Methods Endothelial function was measured using flow-mediated dilation. Glycemic control and glycemic variability were measured using A1C and a continuous glucose monitor, respectively; sleep quality and duration were measured with the Pittsburgh Sleep Quality Index. Results Twenty subjects were recruited. Reduced flow-mediated dilation and higher glucose levels were associated with poorer sleep quality (r = -0.51, P = .01; r = 0.52, P = .03). Subjects with shorter sleep duration had greater glycemic variability. Conclusions Endothelial dysfunction (a precursor to cardiovascular disease) relates to glycemic control, glycemic variability, and sleep quality in T1DM. |
| Databáze: | OpenAIRE |
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