8-Hydroxyquinoline a natural chelating agent from Streptomyces spp. inhibits A549 lung cancer cell lines via BCL2/STAT3 regulating pathways

Autor:	Joseph Devadass Balthazar, Maria Packiam Soosaimanickam, C. Emmanuel, Thirugnansambantham Krishnaraj, Abdullah Sheikh, Saleh Fahad Alghafis, Hairul-Islam Mohamed Ibrahim
Rok vydání:	2022
Předmět:	STAT3 Transcription Factor Lung Neoplasms Physiology Apoptosis General Medicine Oxyquinoline Applied Microbiology and Biotechnology Streptomyces Soil Proto-Oncogene Proteins c-bcl-2 A549 Cells Caspases Cell Line Tumor Humans Cell Proliferation Chelating Agents Biotechnology
Zdroj:	World Journal of Microbiology and Biotechnology. 38
ISSN:	1573-0972 0959-3993
DOI:	10.1007/s11274-022-03368-4
Popis:	Biomolecules from Streptomyces spp. are emerging sources of natural drugs and have been focused on over the decade. The discovery of bioactive chemotherapeutic molecules from soil Streptomyces spp. has opened the medium for the search for natural drugs. In the current study, 8-HOQ was extracted and purified from soil Streptomyces spp. and was evaluated on A549 and BEAS cell lines. The apoptotic and caspase mediated pathways were evaluated using cell proliferation, dual fluorescent staining, migration, invasion and mRNA as well as protein quantification of apoptotic markers. In vitro cytotoxicity test revealed that 8-HOQ possesses potent cytotoxicity activities with IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b8e9cb6a548fdc393f7ab78dda0010 https://doi.org/10.1007/s11274-022-03368-4 Zobrazit plný text záznamu Full text from SpringerLink