Cross-sectional pupillographic evaluation of relative afferent pupillary defect in age-related macular degeneration
| Autor: | Tadasu Sugita, Yosuke Nagasaka, Yasuki Ito, Hiroko Terasaki, Hiroki Kaneko, Taichi Tsunekawa, Kei Takayama |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Fundus Oculi Visual Acuity Observational Study Diagnostic Techniques Ophthalmological 03 medical and health sciences Macular Degeneration 0302 clinical medicine Pupil Disorders Ophthalmology Age related Afferent Pupillary Defect Medicine Humans Fluorescein Angiography age-related macular degeneration Aged Aged 80 and over business.industry pupillometry Pupil General Medicine Macular degeneration bacterial infections and mycoses medicine.disease eye diseases RAPD relative afferent pupillary defect Cross-Sectional Studies Pupillary reflex 030221 ophthalmology & optometry Pupillography Female sense organs business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | To evaluate, using pupillography, the difference between eyes affected by age-related macular degeneration and their contralateral normal eyes with regard to the mean relative afferent pupillary defect (RAPD) score. Also, to ascertain any correlations between this difference in RAPD score and differences in visual acuity or age-related macular degeneration (AMD) dimensions. Measurements were made using the RAPDx pupillographer (Konan Medical, Nishinomiya, Japan), which analyzes pupil response to light stimulation. Both best corrected visual acuity (converted to logMAR) and greatest linear dimension (GLD; calculated on the basis of fluorescence angiography images) were measured. The correlations between RAPD difference and logMAR difference, and GLD difference were then analyzed. The study included 32 patients (18 men, 14 women; mean age = 74.8 ± 9.7 years) who had AMD in 1 eye and a normal fundus in the contralateral eye. Mean resting pupil diameter, mean latency onset of constriction, mean velocity of constriction, and recovery were not significantly different in AMD eyes compared with normal eyes. The mean amplitude of constriction was smaller (P = 0.028), and the mean latency of maximum constriction was shorter (P = 0.0013) in AMD eyes than in normal eyes. Regarding RAPD scores, there was a significant correlation between visual acuity difference and RAPD score differences of both amplitude (P |
| Databáze: | OpenAIRE |
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