Disease Associations with Complotypes, Supratypes and Haplotypes
| Autor: | P. J. Zilko, Roger L. Dawkins, M.J. Garlepp, F.T. Christiansen, P. H. Kay, James McCluskey, Peter Hollingsworth |
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| Rok vydání: | 1983 |
| Předmět: |
Genetics
biology Immunology Haplotype Disease Human leukocyte antigen Major histocompatibility complex Arthritis Rheumatoid Major Histocompatibility Complex Pathogenesis HLA Antigens Myasthenia Gravis biology.protein Humans Lupus Erythematosus Systemic Immunology and Allergy Spondylitis Ankylosing Hormone metabolism Allele Gene Alleles |
| Zdroj: | Immunological Reviews. 70:5-22 |
| ISSN: | 1600-065X 0105-2896 |
| DOI: | 10.1111/j.1600-065x.1983.tb00707.x |
| Popis: | We have used the term supratype to describe combinations of alleles and have examined associations with disease. In RA and insulin-dependent diabetes one or more supratypes appear to be important but their functional significance remains obscure. In MG and SLE the HLA supratype may contain loci involved in immunoregulation, complement synthesis and hormone metabolism. MG induced by D-Pen is associated with Bw35/DR1 rather than A1, B8, DR3. In contrast there is no evidence of a supratype in AS. We have proposed a model for the pathogenesis of sacroiliitis and AS and have postulated two non-linked genes which act stepwise upon HLA-B27. There are cogent reasons for examining the functional effects of known loci within the MHC and particularly those involved in the expression of complement components. |
| Databáze: | OpenAIRE |
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