Asymmetric desymmetrization of meso-vic-diols by carbamoylation catalyzed with a chiral Cu(II) complex

Autor:	Osamu Onomura, Yoshihiro Matsumura, Masaru Mitsuda, Nobuto Ushijima, Kazuya Matsumoto, Yosuke Demizu
Jazyk:	angličtina
Rok vydání:	2006
Předmět:	Asymmetric desymmetrization Organic Chemistry chemistry.chemical_element Biochemistry Desymmetrization Copper Catalysis meso-vic-Diol Chiral copper complex chemistry Drug Discovery Organic chemistry Carbamoylation Trifluoromethanesulfonate
Zdroj:	Tetrahedron Letters. 47(48):8453-8456
ISSN:	0040-4039
Popis:	Asymmetric desymmetrization of meso-vic-diols was achieved by carbamoylation in the presence of copper triflate and (S,S)-Ph-BOX as a catalyst without any use of bases. The method was successfully applied to asymmetric desymmetrization of five- to eight-membered cyclic meso-vic-diols in high enantioselectivity with up to 93% ee. Tetrahedron Letters 47(48) pp.8453-8456, 2006
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b340f68b91b4e81a84207f347c496f http://hdl.handle.net/10069/16333 Zobrazit plný text záznamu Full Text from ScienceDirect