Combined antibacterial/tissue regeneration response in thermal burns promoted by functional chitosan/silver nanocomposites
| Autor: | Gabriel Luna-Bárcenas, J.L. García-Rivas, Evgen Prokhorov, E. Luna-Hernández, R. Muñoz, J.L. Menchaca-Arredondo, Martha Cruz-Soto, Felipe Padilla-Vaca, L. Granados-López, R. A. Mauricio-Sánchez, Diana Guadalupe Ramírez-Wong, Beatriz Liliana España-Sánchez, A. Hernandez-Rangel, L.R. Ovalle-Flores |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Silver Biocompatibility Biocompatible Materials 02 engineering and technology Matrix (biology) urologic and male genital diseases 010402 general chemistry 01 natural sciences Biochemistry Silver nanoparticle Nanocomposites Chitosan chemistry.chemical_compound Structural Biology Animals Regeneration Rats Wistar Molecular Biology Bacterial penetration Nanocomposite urogenital system Chemistry Regeneration (biology) General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Anti-Bacterial Agents Rats 0210 nano-technology Antibacterial activity Burns Nuclear chemistry |
| Zdroj: | International journal of biological macromolecules. 105(Pt 1) |
| ISSN: | 1879-0003 |
| Popis: | We report the combined antibacterial/tissue regeneration responses to thermal burns promoted by functional chitosan/silver nanocomposites (CS/nAg) with ultralow silver content (0.018wt.%, 7-30nm). Our approach allows one to produce CS/nAg nanocomposites without silver nanoparticles (nAg) agglomeration, with bactericide potency higher than 1wt.% of nAg (ca. 10nm) content and, promoting the healing process in controlled thermal burns. CS/nAg films exhibit high antibacterial activity against S. aureus and P. aeruginosa after 1.5h of incubation, demonstrating the bacterial penetration into hydrated films and their interaction with nAg. Additionally, exceptional healing of induced thermal burns was obtained by increasing myofibroblasts, collagen remodeling, and blood vessel neoformation. These factors are associated with epiderma regeneration after 7days of treatment with no nAg release. Our results corroborate the controlled synthesis of nAg embedded in CS matrix with combined antibacterial/biocompatibility properties aiming to produce functional nanocomposites with potential use in wound dressing and health care applications. |
| Databáze: | OpenAIRE |
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