Substituted Pyrazolopyridines as Potent and Selective PDE5 Inhibitors: Potential Agents for Treatment of Erectile Dysfunction
| Autor: | John Krupinski, Saeho Chong, Andrew Henwood, Ximao Wu, Leonard P. Adam, Guixue Yu, Jian Wang, Ronald Pongrac, John E. Macor, Bin He, Gary Dorough, Diane E. Normandin, Helen J. Mason, Laurie Seliger |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Phosphodiesterase Inhibitors Pyridines Muscle Relaxation Administration Oral In Vitro Techniques Pharmacology Structure-Activity Relationship Dogs Erectile Dysfunction 3' 5'-Cyclic-GMP Phosphodiesterases Drug Discovery Pyrazolopyridine medicine Animals Cyclic Nucleotide Phosphodiesterases Type 5 biology Chemistry Phosphoric Diester Hydrolases Muscle Smooth medicine.disease Rats Erectile dysfunction Biochemistry Enzyme inhibitor biology.protein Molecular Medicine Rabbits Penis |
| Zdroj: | Journal of Medicinal Chemistry. 44:1025-1027 |
| ISSN: | 1520-4804 0022-2623 |
| Databáze: | OpenAIRE |
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