High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis
| Autor: | Michael R. Douglas, S. Kalra, J.M. Faint, S.J. Curnow, L.K. Assi, Ghaniah Hassan-Smith, A. Tsentemeidou, Lindsay Durant |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Multiple Sclerosis Immunology Immunoglobulin light chain Sensitivity and Specificity Immunoglobulin kappa-Chains Young Adult Cerebrospinal fluid Nephelometry and Turbidimetry medicine Humans Immunology and Allergy Aged Suspected multiple sclerosis Clinically isolated syndrome business.industry Multiple sclerosis Oligoclonal Bands Middle Aged medicine.disease Highly sensitive Neurology Female Neurology (clinical) business Nephelometry Kappa |
| Zdroj: | Journal of Neuroimmunology. 276:175-179 |
| ISSN: | 0165-5728 |
| Popis: | Cerebrospinal fluid (CSF) analysis is routinely used in the diagnostic work-up of multiple sclerosis (MS), by detecting CSF-specific oligoclonal bands (OCB). More recently, several studies have reported CSF free light chains (FLC) as an alternative. We show that absolute CSF κFLC concentrations were highly sensitive - more than OCB testing - and specific for clinically isolated syndrome, relapsing remitting and primary progressive MS. Measurement of κFLC alone was sufficient. Our results suggest that CSF κFLC levels measured by nephelometry, if validated in a larger series, are a preferred test to OCB analysis in the diagnostic work-up of patients suspected of having MS. |
| Databáze: | OpenAIRE |
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