Anti-thyroid peroxidase antibody positivity during early pregnancy is associated with pregnancy complications and maternal morbidity in later life
Autor: | Sandip Roy Basunia, Kasturi Mukherjee, Madhuri Ranjana Biswas, Anindya Mukherjee, Raghunath Bhattacharyya, Anjan Das |
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Rok vydání: | 2015 |
Předmět: |
postpartum thyroiditis
medicine.medical_specialty endocrine system endocrine system diseases General Biochemistry Genetics and Molecular Biology Thyroid peroxidase Medicine Gynecology Pregnancy biology business.industry Obstetrics Thyroid disease Thyroid General Medicine medicine.disease Anti-thyroid autoantibodies Outpatient department postpartum thyroid dysfunction medicine.anatomical_structure biology.protein Postpartum thyroiditis Original Article Thyroid function business Postpartum period thyroid peroxidase antibody |
Zdroj: | Journal of Natural Science, Biology, and Medicine |
ISSN: | 0976-9668 |
Popis: | Aims: We assessed the impact of detecting anti-thyroid peroxidase antibodies (anti-TPO-Ab) in the first trimester of pregnancy on pregnancy outcomes and maternal thyroid function during the postpartum period. Materials and Methods: In a prospective study consisting 400 pregnant women (8-12 weeks pregnant) were screened for their thyroid profile and followed-up to 12 weeks postpartum. Patients with abnormal thyroid function at 12 weeks postpartum were further followed-up with repeated assessment of thyroid stimulating hormone (TSH) and serum-free thyroxine-4 levels at 8 weeks interval up to 12 months postpartum. Results: 11.5% of the subjects were positive for anti-TPO-Ab who had mean TSH level of 2.31 μIU/ml, which was significantly ( P- 0.0001) higher than pregnant women negative for anti-TPO-Ab (1.73 μIU/ml). Increased incidence of miscarriage was observed in anti-TPO positive mothers when compared to antibody negative mothers. Postpartum thyroid dysfunction developed in 4.7% cases at 12 weeks, among them antibody positivity was observed in 81.25% of subjects. In 18.75% mothers positive for anti-TPO-Ab, the thyroid dysfunction persisted up to 12 months postpartum. Conclusions: Thyroid antibodies detected in early pregnancy seems to be predicting pregnancy complications and later maternal thyroid disease related morbidity. |
Databáze: | OpenAIRE |
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