Emergence of Klebsiella pneumoniae carrying the novel extended-spectrum β-lactamase gene variants blaSHV-40, blaTEM-116 and the class 1 integronassociated blaGES-7 in Brazil
| Autor: | Valéria Cassettari, Maria Helena Matté, Lívia Carminato Balsalobre, Nilton Lincopan, Glavur Rogério Matté, Elsa Masae Mamizuka, Milena Dropa |
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| Rok vydání: | 2010 |
| Předmět: |
DNA
Bacterial Microbiology (medical) blaSHV Sequence analysis Klebsiella pneumoniae medicine.drug_class medicine.medical_treatment Cephalosporin Molecular Sequence Data Ceftazidime Integron beta-Lactamases Microbiology Integrons class 1 integron Cefoxitin Trimethoprim Sulfamethoxazole Drug Combination medicine Humans Aged 80 and over biology General Medicine Sequence Analysis DNA biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification β-lactamase Anti-Bacterial Agents Klebsiella Infections Latin America Infectious Diseases extended-spectrum blaGES Beta-lactamase biology.protein Female Enterobacter cloacae Brazil medicine.drug blaTEM |
| Zdroj: | Clinical Microbiology and Infection. 16(6):630-632 |
| ISSN: | 1198-743X |
| DOI: | 10.1111/j.1469-0691.2009.02944.x |
| Popis: | A clinical Klebsiella pneumoniae isolate carrying the extended-spectrum beta-lactamase gene variants bla(SHV-40), bla(TEM-116) and bla(GES-7) was recovered. Cefoxitin and ceftazidime activity was most affected by the presence of these genes and an additional resistance to trimethoprim-sulphamethoxazole was observed. The bla(GES-7) gene was found to be inserted into a class 1 integron. These results show the emergence of novel bla(TEM) and bla(SHV) genes in Brazil. Moreover, the presence of class 1 integrons suggests a great potential for dissemination of bla(GES) genes into diverse nosocomial pathogens. Indeed, the bla(GES-7) gene was originally discovered in Enterobacter cloacae in Greece and, to our knowledge, has not been reported elsewhere. |
| Databáze: | OpenAIRE |
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